mRNA Covid Vaccines:A Deadly Scientific Mistake

The vaccine is made to the wrong protein! The mRNA vaccines make lots of excess spike proteins to bind ace2, so that the virus cannot infect the cell. Superficially, that approach makes sense. However, what has not been addressed is what does the ace2  protein normally do?

The answer is pretty scary, Ace2  inhibits the pro inflammatory clotting activity that is seen in people who’ve been infected. To put it more succinctly, the vaccine is pro-aging. People who’ve been vaccinated and are not extremely cautious with their diet, to make sure they turn on sufficient fat burning, will die prematurely.

References documenting why ACE2 should not be inhibited.  

Murça, T. M., Moraes, P. L., Capuruço, C. A., Santos, S. H., Melo, M. B., Santos, R. A. et al. (2012). Oral administration of an angiotensin-converting enzyme 2 activator ameliorates diabetes-induced cardiac dysfunction. Regul Pept, 177(1-3), 107-115.

Song, L. N., Liu, J. Y., Shi, T. T., Zhang, Y. C., Xin, Z., Cao, X. et al. (2020). Angiotensin-(1-7), the product of ACE2 ameliorates NAFLD by acting through its receptor Mas to regulate hepatic mitochondrial function and glycolipid metabolism. FASEB J, 34(12), 16291-16306.

Vecchiatto, B., da Silva, R. C., Higa, T. S., Muller, C. R., Américo, A. L. V., Fortunato-Lima, V. C. et al. (2021). Oxidative phenotype induced by aerobic physical training prevents the obesity-linked insulin resistance without changes in gastrocnemius muscle ACE2-Angiotensin(1-7)-Mas axis. Diabetol Metab Syndr, 13(1), 74.

Shen, H., Zhang, J., Wang, C., Jain, P. P., Xiong, M., Shi, X. et al. (2020). MDM2-Mediated Ubiquitination of Angiotensin-Converting Enzyme 2 Contributes to the Development of Pulmonary Arterial Hypertension. Circulation, 142(12), 1190-1204.

Lei, Y., Zhang, J., Schiavon, C. R., He, M., Chen, L., Shen, H. et al. (2020). SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2. bioRxiv, 2020.12.04.409144.

Cai, Y., Zeng, M., & Chen, Y. Z. (2021). The pharmacological mechanism of Huashi Baidu Formula for the treatment of COVID-19 by combined network pharmacology and molecular docking. Ann Palliat Med, 10(4), 3864-3895.

Barbosa, M. A., Barbosa, C. M., Lima, T. C., Dos Santos, R. A. S., & Alzamora, A. C. (2020). The Novel Angiotensin-(1-7) Analog, A-1317, Improves Insulin Resistance by Restoring Pancreatic β-Cell Functionality in Rats With Metabolic Syndrome. Front Pharmacol, 11, 1263.

Lakshmanan, A. P., Harima, M., Sukumaran, V., Soetikno, V., Thandavarayan, R. A., Suzuki, K. et al. (2012). Modulation of AT-1R/AMPK-MAPK cascade plays crucial role for the pathogenesis of diabetic cardiomyopathy in transgenic type 2 diabetic (Spontaneous Diabetic Torii) rats. Biochem Pharmacol, 83(5), 653-660.

Shinshi, Y., Higashiura, K., Yoshida, D., Togashi, N., Yoshida, H., Miyazaki, Y. et al. (2007). Angiotensin II inhibits glucose uptake of skeletal muscle via the adenosine monophosphate-activated protein kinase pathway. J Am Soc Hypertens, 1(4), 251-255.

Yoshida, D., Higashiura, K., Shinshi, Y., Satoh, K., Hyakkoku, M., Yoshida, H. et al. (2009). Effects of angiotensin II receptor blockade on glucose metabolism via AMP-activated protein kinase in insulin-resistant hypertensive rats. J Am Soc Hypertens, 3(1), 3-8.

Kim, E. N., Kim, M. Y., Lim, J. H., Kim, Y., Shin, S. J., Park, C. W. et al. (2018). The protective effect of resveratrol on vascular aging by modulation of the renin-angiotensin system. Atherosclerosis, 270, 123-131.

Surapongchai, J., Rattanavichit, Y., Buniam, J., & Saengsirisuwan, V. (2018). Exercise Protects Against Defective Insulin Signaling and Insulin Resistance of Glucose Transport in Skeletal Muscle of Angiotensin II-Infused Rat. Front Physiol, 9, 358.

Zhang, X., Zheng, J., Yan, Y., Ruan, Z., Su, Y., Wang, J. et al. (2019). Angiotensin-converting enzyme 2 regulates autophagy in acute lung injury through AMPK/mTOR signaling. Arch Biochem Biophys, 672, 108061.

Kim, H. Y., Cha, H. J., & Kim, H. S. (2014). CCL5 upregulates activation of AMP-activated protein kinases in vascular smooth muscle cells of spontaneously hypertensive rats. Cytokine, 67(2), 77-84.

Ding, D. Z., Jia, Y. N., Zhang, B., Guan, C. M., Zhou, S., Li, X. et al. (2019). C‑type natriuretic peptide prevents angiotensin II‑induced atrial connexin 40 and 43 dysregulation by activating AMP‑activated kinase signaling. Mol Med Rep, 20(6), 5091-5099.

Han, Y. M., Lee, Y. J., Jang, Y. N., Kim, H. M., Seo, H. S., Jung, T. W. et al. (2020). Aspirin Improves Nonalcoholic Fatty Liver Disease and Atherosclerosis through Regulation of the PPARδ-AMPK-PGC-1α Pathway in Dyslipidemic Conditions. Biomed Res Int, 2020, 7806860.

Zhao, Y., Wang, L., He, S., Wang, X., & Shi, W. (2017). Nitric oxide synthesis-promoting effects of valsartan in human umbilical vein endothelial cells via the Akt/adenosine monophosphate-activated protein kinase/endothelial nitric oxide synthase pathway. Bosn J Basic Med Sci, 17(2), 132-137.

Morimoto, H., Mori, J., Nakajima, H., Kawabe, Y., Tsuma, Y., Fukuhara, S. et al. (2018). Angiotensin 1-7 stimulates brown adipose tissue and reduces diet-induced obesity. Am J Physiol Endocrinol Metab, 314(2), E131-E138.

Zhang, J., Dong, J., Martin, M., He, M., Gongol, B., Marin, T. L. et al. (2018). AMP-activated Protein Kinase Phosphorylation of Angiotensin-Converting Enzyme 2 in Endothelium Mitigates Pulmonary Hypertension. Am J Respir Crit Care Med, 198(4), 509-520.

Ma, H., Kong, J., Wang, Y. L., Li, J. L., Hei, N. H., Cao, X. R. et al. (2017). Angiotensin-converting enzyme 2 overexpression protects against doxorubicin-induced cardiomyopathy by multiple mechanisms in rats. Oncotarget, 8(15), 24548-24563.

Patel, V. B., Mori, J., McLean, B. A., Basu, R., Das, S. K., Ramprasath, T. et al. (2016). ACE2 Deficiency Worsens Epicardial Adipose Tissue Inflammation and Cardiac Dysfunction in Response to Diet-Induced Obesity. Diabetes, 65(1), 85-95.

Oliveira Andrade, J. M., Paraíso, A. F., Garcia, Z. M., Ferreira, A. V., Sinisterra, R. D., Sousa, F. B. et al. (2014). Cross talk between angiotensin-(1-7)/Mas axis and sirtuins in adipose tissue and metabolism of high-fat feed mice. Peptides, 55, 158-165.

Ahmed, Y. M., Anwar, B., El-Daly, M. E., & Abo-Saif, A. A. (2019). Effects of ticagrelor, empagliflozin and tamoxifen against experimentally-induced vascular reactivity defects in rats in vivo and in vitro. Pharmacol Rep, 71(6), 1034-1043.

Huang, Y., Li, Y., Liu, Q., Zhang, J., Zhang, Z., Wu, T. et al. (2020). Telmisartan attenuates obesity-induced insulin resistance via suppression of AMPK mediated ER stress. Biochem Biophys Res Commun.

Kim, S. A., Lee, K. Y., Kim, J. R., & Choi, H. C. (2016). Estrogenic compound attenuates angiotensin II-induced vascular smooth muscle cell proliferation through interaction between LKB1 and estrogen receptor α. J Pharmacol Sci, 132(1), 78-85.

Su, H., Na, N., Zhang, X., & Zhao, Y. (2017). The biological function and significance of CD74 in immune diseases. Inflamm Res, 66(3), 209-216.

Vasamsetti, S. B., Karnewar, S., Gopoju, R., Gollavilli, P. N., Narra, S. R., Kumar, J. M. et al. (2016). Resveratrol attenuates monocyte-to-macrophage differentiation and associated inflammation via modulation of intracellular GSH homeostasis: Relevance in atherosclerosis. Free Radic Biol Med, 96, 392-405.

Kohlstedt, K., Trouvain, C., Boettger, T., Shi, L., Fisslthaler, B., & Fleming, I. (2013). AMP-activated protein kinase regulates endothelial cell angiotensin-converting enzyme expression via p53 and the post-transcriptional regulation of microRNA-143/145. Circ Res, 112(8), 1150-1158.

Essick, E. E., Wilson, R. M., Pimentel, D. R., Shimano, M., Baid, S., Ouchi, N. et al. (2013). Adiponectin modulates oxidative stress-induced autophagy in cardiomyocytes. PLoS One, 8(7), e68697.

Essick, E. E., Ouchi, N., Wilson, R. M., Ohashi, K., Ghobrial, J., Shibata, R. et al. (2011). Adiponectin mediates cardioprotection in oxidative stress-induced cardiac myocyte remodeling. Am J Physiol Heart Circ Physiol, 301(3), H984-93.

Lee, J. H., Kim, J. H., Kim, J. S., Chang, J. W., Kim, S. B., Park, J. S. et al. (2013). AMP-activated protein kinase inhibits TGF-beta-, angiotensin II-, aldosterone-, high glucose-, and albumin-induced epithelial-mesenchymal transition. Am J Physiol Renal Physiol, 304(6), F686-97.

Bendale, D. S., Karpe, P. A., Chhabra, R., Shete, S. P., Shah, H., & Tikoo, K. (2013). 17-beta Oestradiol prevents cardiovascular dysfunction in post-menopausal metabolic syndrome by affecting SIRT1/AMPK/H3 acetylation. Br J Pharmacol, 170(4), 779-795.

Kim, H. Y., & Kim, H. S. (2014). IL-10 up-regulates CCL5 expression in vascular smooth muscle cells from spontaneously hypertensive rats. Cytokine, 68(1), 40-49.

Liu, L., Liu, J., Tian, X. Y., Wong, W. T., Lau, C. W., Xu, A. et al. (2014). Uncoupling Protein-2 Mediates DPP-4 Inhibitor-Induced Restoration of Endothelial Function in Hypertension Through Reducing Oxidative Stress. Antioxid Redox Signal, 21(11), 1571-1581.