Therapeutic potential of polyphenols in cardiovascular diseases: regulation of mTOR signaling pathway

Pharmacol Res. 2020 Jan 2:104626. doi: 10.1016/j.phrs.2019.104626. [Epub ahead of print]

Therapeutic potential of polyphenols in cardiovascular diseases: regulation of mTOR signaling pathway.

Sanches-Silva A1Testai L2Nabavi SF3Battino M4Devi KP5Tejada S6Sureda A7Xu S8Yousefi B9Majidinia M10Russo GL11Efferth T12Nabavi SM13Farzaei MH14.

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Cardiovascular diseases comprise of non-communicable disorders that involve the heart and/or blood vessels and have become the leading cause of death worldwide with increased prevalence by age. mTORis a serine/threonine-specific protein kinase which play a central role in many physiological processes including cardiovascular diseases, and also integrates various proliferative signals, nutrient and energy abundance and stressful situations. mTOR also act as central regulator during chronic stress, mitochondrial dysfunction and deregulated autophagy which are associated with senescence. Under oxidative stress, mTOR has been reported to exert protective effects regulating apoptosis and autophagy processes and favoring tissue repair. On the other hand, inhibition of mTOR has been suggested to have beneficial effects against atherosclerosis, cardiac hypertrophy and heart failure, and also in extending the lifespan. In this aspect, the use of drugs or natural compounds, which can target mTOR is an interesting approach in order to reduce the number of deaths caused by cardiovascular disease. In the present review, we intend to shed light on the possible effects and molecular mechanism of natural agents like polyphenols via regulating mTOR.


Ascomycin (CID: 5282071); Cardiovascular diseases; Curcumin (PubChem CID: 969516); Epigallocatechingallate (CID: 65064); Honokiol (CID: 72303); Macrolactam FK-506(tacrolimus) (CID: 445643); Metformin (CID: 4091); Oleuropein (CID: 5281544); Polyphenols; Quercetin (CID: 5280343); Rapamycin (CID: 5284616); Resveratrol (CID: 445154); mTORs

PMID: 31904507  DOI: 10.1016/j.phrs.2019.104626

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