Molecular mechanisms of autophagy in regulating renal aging and interventionaleffects of Chinese herbal medicine

[Molecular mechanisms of autophagy in regulating renal aging and interventional effects of Chinese herbal medicine].

[Article in Chinese]

https://www.ncbi.nlm.nih.gov/pubmed/28929674?dopt=Citation

The below quote from the attached article presents aging from the perspective of conventional wisdom, established biological thinking.
"Aging is the gradual functional recession of the living tissues or organs caused by a variety of genetic and environmental factors together"

The far from equilibrium thermodynamic perspective is below
"Life is a flow dependent, far from equilibrium dynamical system. Aging is the time dependent accumulation of free radical modified biochemicals that alter the homeostatic ability of the flow dependent structure until It's complexity decreases and the systemcan no longer extract sufficient negative entropy from the environment to maintain the living state. The system collapses, and undergoes a far from equilibrium phase change to death, a nonlinear decrease in the system's level of flow dependent complexity.

Note That all the herbals mentioned in the abstract below all turn on set for as indicated by AMPK activity.

Abstract
Aging is the gradual functional recession of the living tissues or organs caused by a variety of genetic and environmental factors together. Autophagy is a process of degrading cytoplasmic components mediated by lysosomes in eukaryotic cells. Kidney is a typical target organ of aging. Autophagy regulates renal aging. Decrease in autophagy can accelerate renal aging,whereas,increase in autophagy can delay renal aging. During the process of regulating renal aging,the mammalian target of rapamycin (mTOR) and its related signaling pathways including the adenosine monophosphate activated protein kinase (AMPK)/mTOR,the phosphatidylinositol 3-kinase (PI3K)/ serine-threonine kinase(Akt)/mTOR,the AMPK/silent information regulation 1 (Sirt1) and transforming growth factor β (TGF-β) play the important roles in renal aging. Regulating the key signaling molecules in these pathways in vivo can control renal aging. Some Chinese herbal medicine (CHM) and their extracts with the effects of nourishing kidney or activating stasis, such as Cordyceps sinensis, curcumin and resveratrol have the beneficial effects on renal aging and/or autophagy. Therefore,revealing the pharmacological effects of CHM in anti-renal aging based on the molecular mechanisms of autophagy will become one of the development trends in the future study.

© drbob 2018