Powerful Search Terms

1: Chaturvedi RK, Flint Beal M. Mitochondrial diseases of the brain. Free Radic

Biol Med. 2013 Oct;63:1-29. doi: 10.1016/j.freeradbiomed.2013.03.018. Epub 2013

Apr 6. PMID: 23567191.

2: Lee KA, Cho KC, Kim B, Jang IH, Nam K, Kwon YE, Kim M, Hyeon DY, Hwang D,

Seol JH, Lee WJ. Inflammation-Modulated Metabolic Reprogramming Is Required for

DUOX-Dependent Gut Immunity in Drosophila. Cell Host Microbe. 2018 Mar

14;23(3):338-352.e5. doi: 10.1016/j.chom.2018.01.011. Epub 2018 Mar 1. PMID:


3: Moral-Sanz J, Lewis SA, MacMillan S, Ross FA, Thomson A, Viollet B, Foretz M,

Moran C, Hardie DG, Evans AM. The LKB1-AMPK-α1 signaling pathway triggers

hypoxic pulmonary vasoconstriction downstream of mitochondria. Sci Signal. 2018

Oct 2;11(550):eaau0296. doi: 10.1126/scisignal.aau0296. PMID: 30279167.

4: Griffiths HR, Gao D, Pararasa C. Redox regulation in metabolic programming

and inflammation. Redox Biol. 2017 Aug;12:50-57. doi:

10.1016/j.redox.2017.01.023. Epub 2017 Feb 12. PMID: 28212523; PMCID:


5: Onnis A, Cianfanelli V, Cassioli C, Samardzic D, Pelicci PG, Cecconi F,

Baldari CT. The pro-oxidant adaptor p66SHC promotes B cell mitophagy by

disrupting mitochondrial integrity and recruiting LC3-II. Autophagy.

2018;14(12):2117-2138. doi: 10.1080/15548627.2018.1505153. Epub 2018 Sep 6.

PMID: 30109811; PMCID: PMC6984773.

6: Urano Y, Mori C, Fuji A, Konno K, Yamamoto T, Yashirogi S, Ando M, Saito Y,

Noguchi N. 6-Hydroxydopamine induces secretion of PARK7/DJ-1 via autophagy-based

unconventional secretory pathway. Autophagy. 2018;14(11):1943-1958. doi:

10.1080/15548627.2018.1493043. Epub 2018 Aug 16. PMID: 30112966; PMCID:


7: Piragyte I, Clapes T, Polyzou A, Klein Geltink RI, Lefkopoulos S, Yin N,

Cauchy P, Curtis JD, Klaeylé L, Langa X, Beckmann CCA, Wlodarski MW, Müller P,

Van Essen D, Rambold A, Kapp FG, Mione M, Buescher JM, Pearce EL, Polyzos A,

Trompouki E. A metabolic interplay coordinated by HLX regulates myeloid

differentiation and AML through partly overlapping pathways. Nat Commun. 2018

Aug 6;9(1):3090. doi: 10.1038/s41467-018-05311-4. PMID: 30082823; PMCID:


8: Poillet-Perez L, Despouy G, Delage-Mourroux R, Boyer-Guittaut M. Interplay

between ROS and autophagy in cancer cells, from tumor initiation to cancer

therapy. Redox Biol. 2015;4:184-92. doi: 10.1016/j.redox.2014.12.003. Epub 2014

Dec 10. PMID: 25590798; PMCID: PMC4803791.

9: Zimmermann K, Baldinger J, Mayerhofer B, Atanasov AG, Dirsch VM, Heiss EH.

Activated AMPK boosts the Nrf2/HO-1 signaling axis--A role for the unfolded

protein response. Version 2. Free Radic Biol Med. 2015 Nov;88(Pt B):417-426.

doi: 10.1016/j.freeradbiomed.2015.03.030. Epub 2015 Apr 3. PMID: 25843659;

PMCID: PMC4568300.

10: Lu CC, Chiang JH, Tsai FJ, Hsu YM, Juan YN, Yang JS, Chiu HY. Metformin

triggers the intrinsic apoptotic response in human AGS gastric adenocarcinoma

cells by activating AMPK and suppressing mTOR/AKT signaling. Int J Oncol. 2019

Apr;54(4):1271-1281. doi: 10.3892/ijo.2019.4704. Epub 2019 Jan 30. PMID:

30720062; PMCID: PMC6411354.

11: Finley J. Facilitation of hippocampal long-term potentiation and

reactivation of latent HIV-1 via AMPK activation: Common mechanism of action

linking learning, memory, and the potential eradication of HIV-1. Med

Hypotheses. 2018 Jul;116:61-73. doi: 10.1016/j.mehy.2018.04.018. Epub 2018 Apr

22. PMID: 29857913.

12: Zhao X, Fang J, Li S, Gaur U, Xing X, Wang H, Zheng W. Artemisinin

Attenuated Hydrogen Peroxide (H<sub>2</sub>O<sub>2</sub>)-Induced Oxidative

Injury in SH-SY5Y and Hippocampal Neurons via the Activation of AMPK Pathway.

Int J Mol Sci. 2019 May 31;20(11):2680. doi: 10.3390/ijms20112680. PMID:

31151322; PMCID: PMC6600327.

13: Du J, Wang T, Li Y, Zhou Y, Wang X, Yu X, Ren X, An Y, Wu Y, Sun W, Fan W,

Zhu Q, Wang Y, Tong X. DHA inhibits proliferation and induces ferroptosis of

leukemia cells through autophagy dependent degradation of ferritin. Free Radic

Biol Med. 2019 Feb 1;131:356-369. doi: 10.1016/j.freeradbiomed.2018.12.011. Epub

2018 Dec 14. PMID: 30557609.

14: de Araújo S, Oliveira AP, Sousa FBM, Souza LKM, Pacheco G, Filgueiras MC,

Nicolau LAD, Brito GAC, Cerqueira GS, Silva RO, Souza MHLP, Medeiros JVR. AMPK

activation promotes gastroprotection through mutual interaction with the gaseous

mediators H<sub>2</sub>S, NO, and CO. Nitric Oxide. 2018 Aug 1;78:60-71. doi:

10.1016/j.niox.2018.05.008. Epub 2018 May 30. PMID: 29857061.

15: Fan Y, Yang Q, Yang Y, Gao Z, Ma Y, Zhang L, Liang W, Ding G. Sirt6

Suppresses High Glucose-Induced Mitochondrial Dysfunction and Apoptosis in

Podocytes through AMPK Activation. Int J Biol Sci. 2019 Jan 24;15(3):701-713.

doi: 10.7150/ijbs.29323. PMID: 30745856; PMCID: PMC6367578.

16: Zheng Q, Zhao Y, Guo J, Zhao S, Fei C, Xiao C, Wu D, Wu L, Li X, Chang C.

Iron overload promotes mitochondrial fragmentation in mesenchymal stromal cells

from myelodysplastic syndrome patients through activation of the AMPK/MFF/Drp1

pathway. Cell Death Dis. 2018 May 1;9(5):515. doi: 10.1038/s41419-018-0552-7.

PMID: 29725013; PMCID: PMC5938711.

17: Liu N, Xu L, Shi Y, Zhuang S. Podocyte Autophagy: A Potential Therapeutic

Target to Prevent the Progression of Diabetic Nephropathy. J Diabetes Res.

2017;2017:3560238. doi: 10.1155/2017/3560238. Epub 2017 Apr 23. PMID: 28512641;

PMCID: PMC5420432.

18: Choi YH. ROS-mediated activation of AMPK plays a critical role in

sulforaphane-induced apoptosis and mitotic arrest in AGS human gastric cancer

cells. Gen Physiol Biophys. 2018 Mar;37(2):129-140. doi: 10.4149/gpb_2017026.

PMID: 29593120.

19: Mogavero A, Maiorana MV, Zanutto S, Varinelli L, Bozzi F, Belfiore A, Volpi

CC, Gloghini A, Pierotti MA, Gariboldi M. Metformin transiently inhibits

colorectal cancer cell proliferation as a result of either AMPK activation or

increased ROS production. Sci Rep. 2017 Nov 22;7(1):15992. doi:

10.1038/s41598-017-16149-z. PMID: 29167573; PMCID: PMC5700100.

20: Maeda A, Shirao T, Shirasaya D, Yoshioka Y, Yamashita Y, Akagawa M, Ashida

H. Piperine Promotes Glucose Uptake through ROS-Dependent Activation of the

CAMKK/AMPK Signaling Pathway in Skeletal Muscle. Mol Nutr Food Res. 2018

Jun;62(11):e1800086. doi: 10.1002/mnfr.201800086. Epub 2018 May 17. PMID:


21: Le DT, Jung S, Quynh NTN, Sandag Z, Lee BS, Kim S, Lee H, Lee H, Lee MS.

Inhibitory role of AMP‑activated protein kinase in necroptosis of HCT116 colon

cancer cells with p53 null mutation under nutrient starvation. Int J Oncol. 2019

Feb;54(2):702-712. doi: 10.3892/ijo.2018.4634. Epub 2018 Nov 14. PMID: 30431068.

22: Li S, Gaur U, Chong CM, Lin S, Fang J, Zeng Z, Wang H, Zheng W. Berberine

Protects Human Retinal Pigment Epithelial Cells from Hydrogen Peroxide-Induced

Oxidative Damage through Activation of AMPK. Int J Mol Sci. 2018 Jun

12;19(6):1736. doi: 10.3390/ijms19061736. PMID: 29895743; PMCID: PMC6032421.

23: Hwang HJ, Jung TW, Kim JW, Kim JA, Lee YB, Hong SH, Roh E, Choi KM, Baik SH,

Yoo HJ. Protectin DX prevents H<sub>2</sub>O<sub>2</sub>-mediated oxidative

stress in vascular endothelial cells via an AMPK-dependent mechanism. Cell

Signal. 2019 Jan;53:14-21. doi: 10.1016/j.cellsig.2018.09.011. Epub 2018 Sep 20.

PMID: 30244170.

24: Zakłos-Szyda M, Pawlik N. Japanese quince (Chaenomeles japonica L.) fruit

polyphenolic extract modulates carbohydrate metabolism in HepG2 cells via AMP-

activated protein kinase. Acta Biochim Pol. 2018;65(1):67-78. doi:

10.18388/abp.2017_1604. Epub 2018 Mar 1. PMID: 29494709.

25: Choi YH. Schisandrin A prevents oxidative stress-induced DNA damage and

apoptosis by attenuating ROS generation in C2C12 cells. Biomed Pharmacother.

2018 Oct;106:902-909. doi: 10.1016/j.biopha.2018.07.035. Epub 2018 Jul 12. PMID:


26: O'Sullivan TE, Johnson LR, Kang HH, Sun JC. BNIP3- and BNIP3L-Mediated

Mitophagy Promotes the Generation of Natural Killer Cell Memory. Immunity. 2015

Aug 18;43(2):331-42. doi: 10.1016/j.immuni.2015.07.012. Epub 2015 Aug 4. PMID:

26253785; PMCID: PMC5737626.

27: Grossini E, Farruggio S, Raina G, Mary D, Deiro G, Gentilli S. Effects of

Genistein on Differentiation and Viability of Human Visceral Adipocytes.

Nutrients. 2018 Jul 27;10(8):978. doi: 10.3390/nu10080978. PMID: 30060502;

PMCID: PMC6115928.

28: Chu J, Han W. Punicalagin Exerts Beneficial Functions in 6-Hydroxydopamine-

Treated SH-SY5Y Cells by Attenuating Mitochondrial Dysfunction and Inflammatory

Responses. Med Sci Monit. 2018 Aug 25;24:5905-5913. doi: 10.12659/MSM.909969.

PMID: 30143600; PMCID: PMC6120163.

29: Wu W, Wang S, Liu Q, Wang X, Shan T, Wang Y. Cathelicidin-WA attenuates LPS-

induced inflammation and redox imbalance through activation of AMPK signaling.

Free Radic Biol Med. 2018 Dec;129:338-353. doi:

10.1016/j.freeradbiomed.2018.09.045. Epub 2018 Sep 28. PMID: 30273672.

30: Kratchmarov R, Viragova S, Kim MJ, Rothman NJ, Liu K, Reizis B, Reiner SL.

Metabolic control of cell fate bifurcations in a hematopoietic progenitor

population. Immunol Cell Biol. 2018 Sep;96(8):863-871. doi: 10.1111/imcb.12040.

Epub 2018 Apr 6. PMID: 29570858; PMCID: PMC6146018.

31: Wang C, Mao C, Lou Y, Xu J, Wang Q, Zhang Z, Tang Q, Zhang X, Xu H, Feng Y.

Monotropein promotes angiogenesis and inhibits oxidative stress-induced

autophagy in endothelial progenitor cells to accelerate wound healing. J Cell

Mol Med. 2018 Mar;22(3):1583-1600. doi: 10.1111/jcmm.13434. Epub 2017 Dec 26.

PMID: 29278309; PMCID: PMC5824424.

32: Park SY, Jin ML, Yi EH, Kim Y, Park G. Neochlorogenic acid inhibits against

LPS-activated inflammatory responses through up-regulation of Nrf2/HO-1 and

involving AMPK pathway. Environ Toxicol Pharmacol. 2018 Sep;62:1-10. doi:

10.1016/j.etap.2018.06.001. Epub 2018 Jun 8. PMID: 29908432.

33: Lamphier M, Zheng W, Latz E, Spyvee M, Hansen H, Rose J, Genest M, Yang H,

Shaffer C, Zhao Y, Shen Y, Liu C, Liu D, Mempel TR, Rowbottom C, Chow J, Twine

NC, Yu M, Gusovsky F, Ishizaka ST. Novel small molecule inhibitors of TLR7 and

TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014

Mar;85(3):429-40. doi: 10.1124/mol.113.089821. Epub 2013 Dec 16. PMID: 24342772.

34: Chen X, Zhao X, Cai H, Sun H, Hu Y, Huang X, Kong W, Kong W. The role of

sodium hydrosulfide in attenuating the aging process via PI3K/AKT and

CaMKKβ/AMPK pathways. Redox Biol. 2017 Aug;12:987-1003. doi:

10.1016/j.redox.2017.04.031. Epub 2017 Apr 25. PMID: 28499253; PMCID:


35: Liu Y, Liao L, Chen Y, Han F. Effects of daphnetin on lipid metabolism,

insulin resistance and oxidative stress in OA‑treated HepG2 cells. Mol Med Rep.

2019 Jun;19(6):4673-4684. doi: 10.3892/mmr.2019.10139. Epub 2019 Apr 5. PMID:

30957185; PMCID: PMC6522799.

36: Ou HC, Pandey S, Hung MY, Huang SH, Hsu PT, Day CH, Pai P, Viswanadha VP,

Kuo WW, Huang CY. Luteolin: A Natural Flavonoid Enhances the Survival of HUVECs

against Oxidative Stress by Modulating AMPK/PKC Pathway. Am J Chin Med.

2019;47(3):541-557. doi: 10.1142/S0192415X19500289. Epub 2019 Apr 9. PMID:


37: Qiu L, Luo Y, Chen X. Quercetin attenuates mitochondrial dysfunction and

biogenesis via upregulated AMPK/SIRT1 signaling pathway in OA rats. Biomed

Pharmacother. 2018 Jul;103:1585-1591. doi: 10.1016/j.biopha.2018.05.003. Epub

2018 May 7. PMID: 29864946.

38: Das DN, Naik PP, Mukhopadhyay S, Panda PK, Sinha N, Meher BR, Bhutia SK.

Elimination of dysfunctional mitochondria through mitophagy suppresses

benzo[a]pyrene-induced apoptosis. Free Radic Biol Med. 2017 Nov;112:452-463.

doi: 10.1016/j.freeradbiomed.2017.08.020. Epub 2017 Aug 24. PMID: 28843778.

39: Fazakerley DJ, Minard AY, Krycer JR, Thomas KC, Stöckli J, Harney DJ,

Burchfield JG, Maghzal GJ, Caldwell ST, Hartley RC, Stocker R, Murphy MP, James

DE. Mitochondrial oxidative stress causes insulin resistance without disrupting

oxidative phosphorylation. J Biol Chem. 2018 May 11;293(19):7315-7328. doi:

10.1074/jbc.RA117.001254. Epub 2018 Mar 29. PMID: 29599292; PMCID: PMC5950018.

40: Chen R, Cui Y, Zhang X, Zhang Y, Chen M, Zhou T, Lan X, Dong W, Pan C.

Chlorpyrifos Induction of Testicular-Cell Apoptosis through Generation of

Reactive Oxygen Species and Phosphorylation of AMPK. J Agric Food Chem. 2018 Nov

28;66(47):12455-12470. doi: 10.1021/acs.jafc.8b03407. Epub 2018 Nov 15. PMID:


41: Hu J, Cui W, Ding W, Gu Y, Wang Z, Fan W. Globular Adiponectin Attenuated

H2O2-Induced Apoptosis in Rat Chondrocytes by Inducing Autophagy Through the

AMPK/ mTOR Pathway. Cell Physiol Biochem. 2017;43(1):367-382. doi:

10.1159/000480416. Epub 2017 Aug 31. PMID: 28957801.

42: Zhang X, Feng Y, Wang Y, Wang J, Xiang D, Niu W, Yuan F. Resveratrol

ameliorates disorders of mitochondrial biogenesis and dynamics in a rat chronic

ocular hypertension model. Life Sci. 2018 Aug 15;207:234-245. doi:

10.1016/j.lfs.2018.06.010. Epub 2018 Jun 9. PMID: 29894715.

43: Bianchi G, Ravera S, Traverso C, Amaro A, Piaggio F, Emionite L, Bachetti T,

Pfeffer U, Raffaghello L. Curcumin induces a fatal energetic impairment in tumor

cells in vitro and in vivo by inhibiting ATP-synthase activity. Carcinogenesis.

2018 Sep 21;39(9):1141-1150. doi: 10.1093/carcin/bgy076. PMID: 29860383.

44: Ou HC, Chou WC, Chu PM, Hsieh PL, Hung CH, Tsai KL. Fucoxanthin Protects

against oxLDL-Induced Endothelial Damage via Activating the AMPK-Akt-CREB-PGC1α

Pathway. Mol Nutr Food Res. 2019 May;63(10):e1801353. doi:

10.1002/mnfr.201801353. Epub 2019 Apr 10. PMID: 30892786.

45: Hu C, Zhang H, Qiao Z, Wang Y, Zhang P, Yang D. Loss of thioredoxin 2 alters

mitochondrial respiratory function and induces cardiomyocyte hypertrophy. Exp

Cell Res. 2018 Nov 1;372(1):61-72. doi: 10.1016/j.yexcr.2018.09.010. Epub 2018

Sep 17. PMID: 30236513.

46: Wang Y, Han X, Fu M, Wang J, Song Y, Liu Y, Zhang J, Zhou J, Ge J.

Qiliqiangxin attenuates hypoxia-induced injury in primary rat cardiac

microvascular endothelial cells via promoting HIF-1α-dependent glycolysis. J

Cell Mol Med. 2018 May;22(5):2791-2803. doi: 10.1111/jcmm.13572. Epub 2018 Mar

4. PMID: 29502357; PMCID: PMC5908112.

47: Jiang S, Park DW, Gao Y, Ravi S, Darley-Usmar V, Abraham E, Zmijewski JW.

Participation of proteasome-ubiquitin protein degradation in autophagy and the

activation of AMP-activated protein kinase. Cell Signal. 2015 Jun;27(6):1186-97.

doi: 10.1016/j.cellsig.2015.02.024. Epub 2015 Feb 26. PMID: 25728513; PMCID:


48: Yuan H, Hu Y, Zhu Y, Zhang Y, Luo C, Li Z, Wen T, Zhuang W, Zou J, Hong L,

Zhang X, Hisatome I, Yamamoto T, Cheng J. Metformin ameliorates high uric acid-

induced insulin resistance in skeletal muscle cells. Mol Cell Endocrinol. 2017

Mar 5;443:138-145. doi: 10.1016/j.mce.2016.12.025. Epub 2016 Dec 30. PMID:


49: Dai SH, Chen T, Li X, Yue KY, Luo P, Yang LK, Zhu J, Wang YH, Fei Z, Jiang

XF. Sirt3 confers protection against neuronal ischemia by inducing autophagy:

Involvement of the AMPK-mTOR pathway. Free Radic Biol Med. 2017 Jul;108:345-353.

doi: 10.1016/j.freeradbiomed.2017.04.005. Epub 2017 Apr 7. PMID: 28396174.

50: Wang L, Zhang S, Cheng H, Lv H, Cheng G, Ci X. Nrf2-mediated liver

protection by esculentoside A against acetaminophen toxicity through the

AMPK/Akt/GSK3β pathway. Free Radic Biol Med. 2016 Dec;101:401-412. doi:

10.1016/j.freeradbiomed.2016.11.009. Epub 2016 Nov 9. PMID: 27836781.

51: Li M, Zhao J, Hu Y, Lu H, Guo J. Oxygen free radicals regulate energy

metabolism via AMPK pathway following cerebral ischemia. Neurol Res. 2010

Sep;32(7):779-84. doi: 10.1179/174313209X459174. Epub 2009 Aug 5. PMID:


52: Frasca D, Diaz A, Romero M, Thaller S, Blomberg BB. Metabolic requirements

of human pro-inflammatory B cells in aging and obesity. PLoS One. 2019 Jul

9;14(7):e0219545. doi: 10.1371/journal.pone.0219545. PMID: 31287846; PMCID:


53: Puthanveetil P, Rodrigues B. Glucocorticoid excess induces accumulation of

cardiac glycogen and triglyceride: suggested role for AMPK. Curr Pharm Des.

2013;19(27):4818-30. doi: 10.2174/13816128113199990340. PMID: 23323614.

54: Jiang B, Le L, Liu H, Xu L, He C, Hu K, Peng Y, Xiao P. Marein protects

against methylglyoxal-induced apoptosis by activating the AMPK pathway in PC12

cells. Free Radic Res. 2016;50(11):1173-1187. doi:

10.1080/10715762.2016.1222374. Epub 2016 Sep 6. PMID: 27596733.

55: Rabenau M, Unger M, Drewe J, Culmsee C. Metabolic switch induced by

Cimicifuga racemosa extract prevents mitochondrial damage and oxidative cell

death. Phytomedicine. 2019 Jan;52:107-116. doi: 10.1016/j.phymed.2018.09.177.

Epub 2018 Sep 17. PMID: 30599889.

56: Zhao D, Sun X, Lv S, Sun M, Guo H, Zhai Y, Wang Z, Dai P, Zheng L, Ye M,

Wang X. Salidroside attenuates oxidized low‑density lipoprotein‑induced

endothelial cell injury via promotion of the AMPK/SIRT1 pathway. Int J Mol Med.

2019 Jun;43(6):2279-2290. doi: 10.3892/ijmm.2019.4153. Epub 2019 Apr 1. PMID:

30942428; PMCID: PMC6488166.

57: Li S, Sun X, Xu L, Sun R, Ma Z, Deng X, Liu B, Fu Q, Qu R, Ma S. Baicalin

attenuates in vivo and in vitro hyperglycemia-exacerbated ischemia/reperfusion

injury by regulating mitochondrial function in a manner dependent on AMPK. Eur J

Pharmacol. 2017 Nov 15;815:118-126. doi: 10.1016/j.ejphar.2017.07.041. Epub 2017

Jul 22. PMID: 28743390.

58: Lee HJ, Lee JO, Kim N, Kim JK, Kim HI, Lee YW, Kim SJ, Choi JI, Oh Y, Kim

JH, Suyeon-Hwang, Park SH, Kim HS. Irisin, a Novel Myokine, Regulates Glucose

Uptake in Skeletal Muscle Cells via AMPK. Mol Endocrinol. 2015 Jun;29(6):873-81.

doi: 10.1210/me.2014-1353. Epub 2015 Mar 31. PMID: 25826445; PMCID: PMC5414737.

59: Swegen A, Lambourne SR, Aitken RJ, Gibb Z. Rosiglitazone Improves Stallion

Sperm Motility, ATP Content, and Mitochondrial Function. Biol Reprod. 2016

Nov;95(5):107. doi: 10.1095/biolreprod.116.142687. Epub 2016 Sep 28. PMID:


60: Seo K, Ki SH, Shin SM. Sestrin2-AMPK activation protects mitochondrial

function against glucose deprivation-induced cytotoxicity. Cell Signal. 2015

Jul;27(7):1533-43. doi: 10.1016/j.cellsig.2015.03.003. Epub 2015 Mar 14. PMID:


61: Kim MY, Bo HH, Choi EO, Kwon DH, Kim HJ, Ahn KI, Ji SY, Jeong JW, Park SH,

Hong SH, Kim GY, Park C, Kim HS, Moon SK, Yun SJ, Kim WJ, Choi YH. Induction of

Apoptosis by Citrus unshiu Peel in Human Breast Cancer MCF-7 Cells: Involvement

of ROS-Dependent Activation of AMPK. Biol Pharm Bull. 2018;41(5):713-721. doi:

10.1248/bpb.b17-00898. PMID: 29709909.

62: Gao J, Xu Y, Zhang J, Shi J, Gong Q. Lithocarpus polystachyus Rehd. leaves

aqueous extract protects against hydrogen peroxide‑induced SH-SY5Y cells injury

through activation of Sirt3 signaling pathway. Int J Mol Med. 2018

Dec;42(6):3485-3494. doi: 10.3892/ijmm.2018.3916. Epub 2018 Oct 5. PMID:


63: Han L, Yang Q, Li J, Cheng F, Zhang Y, Li Y, Wang M. Protocatechuic Acid-

Ameliorated Endothelial Oxidative Stress through Regulating Acetylation Level

via CD36/AMPK Pathway. J Agric Food Chem. 2019 Jun 26;67(25):7060-7072. doi:

10.1021/acs.jafc.9b02647. Epub 2019 Jun 18. PMID: 31240928.

64: Seo K, Seo S, Ki SH, Shin SM. Compound C Increases Sestrin2 Expression via

Mitochondria-Dependent ROS Production. Biol Pharm Bull. 2016;39(5):799-806. doi:

10.1248/bpb.b15-00938. PMID: 27150150.

65: Kim MJ, Hwang JW, Yun CK, Lee Y, Choi YS. Delivery of exogenous mitochondria

via centrifugation enhances cellular metabolic function. Sci Rep. 2018 Feb

20;8(1):3330. doi: 10.1038/s41598-018-21539-y. PMID: 29463809; PMCID:


66: Choi YH. Diallyl trisulfide induces apoptosis and mitotic arrest in AGS

human gastric carcinoma cells through reactive oxygen species-mediated

activation of AMP-activated protein kinase. Biomed Pharmacother. 2017

Oct;94:63-71. doi: 10.1016/j.biopha.2017.07.055. Epub 2017 Jul 26. PMID:


67: Yu H, Zhang H, Dong M, Wu Z, Shen Z, Xie Y, Kong Z, Dai X, Xu B. Metabolic

reprogramming and AMPKα1 pathway activation by caulerpin in colorectal cancer

cells. Int J Oncol. 2017 Jan;50(1):161-172. doi: 10.3892/ijo.2016.3794. Epub

2016 Dec 6. PMID: 27922662.

68: Zhu Z, Li R, Lv Y, Zeng W. Melatonin protects rabbit spermatozoa from cryo-

damage via decreasing oxidative stress. Cryobiology. 2019 Jun;88:1-8. doi:

10.1016/j.cryobiol.2019.04.009. Epub 2019 Apr 26. PMID: 31034812.

69: Huang Q, Cao H, Zhan L, Sun X, Wang G, Li J, Guo X, Ren T, Wang Z, Lyu Y,

Liu B, An J, Xing J. Mitochondrial fission forms a positive feedback loop with

cytosolic calcium signaling pathway to promote autophagy in hepatocellular

carcinoma cells. Cancer Lett. 2017 Sep 10;403:108-118. doi:

10.1016/j.canlet.2017.05.034. Epub 2017 Jun 15. PMID: 28624623.

70: Ghimire K, Zaric J, Alday-Parejo B, Seebach J, Bousquenaud M, Stalin J,

Bieler G, Schnittler HJ, Rüegg C. MAGI1 Mediates eNOS Activation and NO

Production in Endothelial Cells in Response to Fluid Shear Stress. Cells. 2019

Apr 27;8(5):388. doi: 10.3390/cells8050388. PMID: 31035633; PMCID: PMC6562810.

71: Cho KJ, Casteel DE, Prakash P, Tan L, van der Hoeven D, Salim AA, Kim C,

Capon RJ, Lacey E, Cunha SR, Gorfe AA, Hancock JF. AMPK and Endothelial Nitric

Oxide Synthase Signaling Regulates K-Ras Plasma Membrane Interactions via Cyclic

GMP-Dependent Protein Kinase 2. Mol Cell Biol. 2016 Nov 28;36(24):3086-3099.

doi: 10.1128/MCB.00365-16. PMID: 27697864; PMCID: PMC5126295.

72: Kullmann FA, McDonnell BM, Wolf-Johnston AS, Kanai AJ, Shiva S, Chelimsky T,

Rodriguez L, Birder LA. Stress-induced autonomic dysregulation of mitochondrial

function in the rat urothelium. Neurourol Urodyn. 2019 Feb;38(2):572-581. doi:

10.1002/nau.23876. Epub 2018 Dec 21. PMID: 30575113.

73: Napoli E, Liu S, Marsilio I, Zarbalis K, Giulivi C. Lipid-based DNA/siRNA

transfection agents disrupt neuronal bioenergetics and mitophagy. Biochem J.

2017 Nov 10;474(23):3887-3902. doi: 10.1042/BCJ20170632. PMID: 29025974.

74: Ruze A, Chen BD, Liu F, Chen XC, Gai MT, Li XM, Ma YT, Du XJ, Yang YN, Gao

XM. Macrophage migration inhibitory factor plays an essential role in ischemic

preconditioning-mediated cardioprotection. Clin Sci (Lond). 2019 Mar

5;133(5):665-680. doi: 10.1042/CS20181013. PMID: 30804219.

75: Karnewar S, Vasamsetti SB, Gopoju R, Kanugula AK, Ganji SK, Prabhakar S,

Rangaraj N, Tupperwar N, Kumar JM, Kotamraju S. Mitochondria-targeted esculetin

alleviates mitochondrial dysfunction by AMPK-mediated nitric oxide and SIRT3

regulation in endothelial cells: potential implications in atherosclerosis. Sci

Rep. 2016 Apr 11;6:24108. doi: 10.1038/srep24108. PMID: 27063143; PMCID:


76: Kekulandara DN, Nagi S, Seo H, Chow CS, Ahn YH. Redox-Inactive Peptide

Disrupting Trx1-Ask1 Interaction for Selective Activation of Stress Signaling.

Biochemistry. 2018 Feb 6;57(5):772-780. doi: 10.1021/acs.biochem.7b01083. Epub

2018 Jan 5. PMID: 29261301; PMCID: PMC5856478.

77: Chi JH, Seo GS, Lee SH. Oregonin inhibits inflammation and protects against

barrier disruption in intestinal epithelial cells. Int Immunopharmacol. 2018

Jun;59:134-140. doi: 10.1016/j.intimp.2018.04.006. Epub 2018 Apr 11. PMID:


78: Lee DH, Han DH, Nam KT, Park JS, Kim SH, Lee M, Kim G, Min BS, Cha BS, Lee

YS, Sung SH, Jeong H, Ji HW, Lee MJ, Lee JS, Lee HY, Chun Y, Kim J, Komatsu M,

Lee YH, Bae SH. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that

protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol

Med. 2016 Oct;99:520-532. doi: 10.1016/j.freeradbiomed.2016.09.009. Epub 2016

Sep 12. PMID: 27634173.

79: Chun-Fang, Zhang BB, Lin-Han, Gao CF, Min-Wang. d-Fagomine Attenuates High

Glucose-Induced Endothelial Cell Oxidative Damage by Upregulating the Expression

of PGC-1α. J Agric Food Chem. 2018 Mar 21;66(11):2758-2764. doi:

10.1021/acs.jafc.7b05942. Epub 2018 Feb 28. PMID: 29489344.

80: Zhang Y, Chen H, Fan Y, Yang Y, Gao J, Xu W, Xu Z, Li Z, Tao L. Cytotoxic

effects of bio-pesticide spinosad on human lung A549 cells. Chemosphere. 2019

Sep;230:182-189. doi: 10.1016/j.chemosphere.2019.05.042. Epub 2019 May 6. PMID:


81: Wang M, Wang R, Xie X, Sun G, Sun X. Araloside C protects H9c2

cardiomyoblasts against oxidative stress via the modulation of mitochondrial

function. Biomed Pharmacother. 2019 Sep;117:109143. doi:

10.1016/j.biopha.2019.109143. Epub 2019 Jul 8. PMID: 31387189.

82: Yu J, Zheng J, Lu J, Sun Z, Wang Z, Zhang J. AdipoRon Protects Against

Secondary Brain Injury After Intracerebral Hemorrhage via Alleviating

Mitochondrial Dysfunction: Possible Involvement of AdipoR1-AMPK-PGC1α Pathway.

Neurochem Res. 2019 Jul;44(7):1678-1689. doi: 10.1007/s11064-019-02794-5. Epub

2019 Apr 13. PMID: 30982205.

83: Zhang JJ, Wang XZ, Luong Do H, Chandimali N, Kang TY, Kim N, Ghosh M, Lee

SB, Mok YS, Kim SB, Kwon T, Jeong DK. MicroRNA-7450 regulates non-thermal

plasma-induced chicken Sertoli cell apoptosis via adenosine monophosphate-

activated protein kinase activation. Sci Rep. 2018 Jun 8;8(1):8761. doi:

10.1038/s41598-018-27123-8. PMID: 29884805; PMCID: PMC5993736.

84: Lee G, Park JS, Lee EJ, Ahn JH, Kim HS. Anti-inflammatory and antioxidant

mechanisms of urolithin B in activated microglia. Phytomedicine. 2019 Mar

1;55:50-57. doi: 10.1016/j.phymed.2018.06.032. Epub 2018 Jun 20. PMID: 30668443.

85: Balteau M, Van Steenbergen A, Timmermans AD, Dessy C, Behets-Wydemans G,

Tajeddine N, Castanares-Zapatero D, Gilon P, Vanoverschelde JL, Horman S, Hue L,

Bertrand L, Beauloye C. AMPK activation by glucagon-like peptide-1 prevents

NADPH oxidase activation induced by hyperglycemia in adult cardiomyocytes. Am J

Physiol Heart Circ Physiol. 2014 Oct 15;307(8):H1120-33. doi:

10.1152/ajpheart.00210.2014. Epub 2014 Aug 15. PMID: 25128166.

86: Xie L, Li X, Mo J, Li L, Chen X, Chen L, Ma L, Chen Y, Ge F, Zhao J, Ge RS.

Delayed Puberty by Ziram Is Associated with Down Regulation of Testicular

Phosphorylated AKT1 and SIRT1/PGC-1α Signaling. Chem Res Toxicol. 2018 Dec

17;31(12):1315-1322. doi: 10.1021/acs.chemrestox.8b00201. Epub 2018 Nov 27.

PMID: 30422632.

87: Li D, Chen A, Lan T, Zou Y, Zhao L, Yang P, Qu H, Wei L, Varghese Z,

Moorhead JF, Chen Y, Ruan XZ. SCAP knockdown in vascular smooth muscle cells

alleviates atherosclerosis plaque formation via up-regulating autophagy in

ApoE<sup>-/-</sup> mice. FASEB J. 2019 Mar;33(3):3437-3450. doi:

10.1096/fj.201800975RRR. Epub 2018 Nov 21. PMID: 30462530.

88: Zaha VG, Qi D, Su KN, Palmeri M, Lee HY, Hu X, Wu X, Shulman GI, Rabinovitch

PS, Russell RR 3rd, Young LH. AMPK is critical for mitochondrial function during

reperfusion after myocardial ischemia. J Mol Cell Cardiol. 2016 Feb;91:104-13.

doi: 10.1016/j.yjmcc.2015.12.032. Epub 2015 Dec 30. PMID: 26746142; PMCID:


89: Hou Y, Wang L, Ding B, Liu Y, Zhu H, Liu J, Li Y, Kang P, Yin Y, Wu G.

Alpha-Ketoglutarate and intestinal function. Front Biosci (Landmark Ed). 2011

Jan 1;16:1186-96. doi: 10.2741/3783. PMID: 21196226.

90: Luan G, Wang Y, Wang Z, Zhou W, Hu N, Li G, Wang H. Flavonoid Glycosides

from Fenugreek Seeds Regulate Glycolipid Metabolism by Improving Mitochondrial

Function in 3T3-L1 Adipocytes in Vitro. J Agric Food Chem. 2018 Mar

28;66(12):3169-3178. doi: 10.1021/acs.jafc.8b00179. Epub 2018 Mar 15. PMID:


91: Wu C, Hu S, Wang N, Tian J. Dipeptidyl peptidase‑4 inhibitor sitagliptin

prevents high glucose‑induced apoptosis via activation of AMP‑activated protein

kinase in endothelial cells. Mol Med Rep. 2017 Jun;15(6):4346-4351. doi:

10.3892/mmr.2017.6501. Epub 2017 Apr 21. PMID: 28440488.

92: Keeley TP, Siow RCM, Jacob R, Mann GE. A PP2A-mediated feedback mechanism

controls Ca<sup>2+</sup>-dependent NO synthesis under physiological oxygen.

FASEB J. 2017 Dec;31(12):5172-5183. doi: 10.1096/fj.201700211R. Epub 2017 Jul

31. PMID: 28760745; PMCID: PMC5690389.

93: Sun Y, Peng X, Li Y, Ma H, Li D, Shi X. The effects of histamine H1 type

receptor (H1R) in regulating osteoblastic cell differentiation and

mineralization. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):1281-1287. doi:

10.1080/21691401.2019.1596924. PMID: 30942635.

94: Rossetti ML, Steiner JL, Gordon BS. Increased mitochondrial turnover in the

skeletal muscle of fasted, castrated mice is related to the magnitude of

autophagy activation and muscle atrophy. Mol Cell Endocrinol. 2018 Sep

15;473:178-185. doi: 10.1016/j.mce.2018.01.017. Epub 2018 Feb 1. PMID: 29378237.

95: Liu Y, Wang M, Wang D, Li X, Wang W, Lou H, Yuan H. Malformin A1 promotes

cell death through induction of apoptosis, necrosis and autophagy in prostate

cancer cells. Cancer Chemother Pharmacol. 2016 Jan;77(1):63-75. doi:

10.1007/s00280-015-2915-4. Epub 2015 Dec 8. PMID: 26645406.

96: Jang MH, Kim KY, Song PH, Baek SY, Seo HL, Lee EH, Lee SG, Park KI, Ahn SC,

Kim SC, Kim YW. Moutan Cortex Protects Hepatocytes against Oxidative Injury

through AMP-Activated Protein Kinase Pathway. Biol Pharm Bull.

2017;40(6):797-806. doi: 10.1248/bpb.b16-00884. PMID: 28566623.

97: Fan L, Wang J, Ma C. Pretreatment of bone mesenchymal stem cells with

miR181-c facilitates craniofacial defect reconstruction via activating AMPK-Mfn1

signaling pathways. J Recept Signal Transduct Res. 2019 Jun;39(3):199-207. doi:

10.1080/10799893.2019.1652649. Epub 2019 Aug 30. PMID: 31466503.

98: Xiong Y, Ren L, Wang Z, Hu Z, Zhou Y. Anti-proliferative Effect of Physcion

on Human Gastric Cell Line via Inducing ROS-Dependent Apoptosis. Cell Biochem

Biophys. 2015 Nov;73(2):537-543. doi: 10.1007/s12013-015-0674-9. PMID: 27352350.

99: Kim HJ, Park C, Han MH, Hong SH, Kim GY, Hong SH, Kim ND, Choi YH. Baicalein

Induces Caspase-dependent Apoptosis Associated with the Generation of ROS and

the Activation of AMPK in Human Lung Carcinoma A549 Cells. Drug Dev Res. 2016

Mar;77(2):73-86. doi: 10.1002/ddr.21298. Epub 2016 Mar 12. PMID: 26971531.

100: Hao Y, Liu HM, Wei X, Gong X, Lu ZY, Huang ZH. Diallyl trisulfide

attenuates hyperglycemia-induced endothelial apoptosis by inhibition of

Drp1-mediated mitochondrial fission. Acta Diabetol. 2019 Nov;56(11):1177-1189.

doi: 10.1007/s00592-019-01366-x. Epub 2019 May 21. PMID: 31115753; PMCID:


101: Shabani Nashtaei M, Amidi F, Sedighi Gilani MA, Aleyasin A, Bakhshalizadeh

S, Naji M, Nekoonam S. Protective features of resveratrol on human spermatozoa

cryopreservation may be mediated through 5' AMP-activated protein kinase

activation. Andrology. 2017 Mar;5(2):313-326. doi: 10.1111/andr.12306. Epub 2016

Dec 19. PMID: 27992972.

102: Knupp J, Martinez-Montañés F, Van Den Bergh F, Cottier S, Schneiter R,

Beard D, Chang A. Sphingolipid accumulation causes mitochondrial dysregulation

and cell death. Cell Death Differ. 2017 Dec;24(12):2044-2053. doi:

10.1038/cdd.2017.128. Epub 2017 Aug 11. PMID: 28800132; PMCID: PMC5686345.

103: Gonçalves CFL, de Freitas ML, Fortunato RS, Miranda-Alves L, Carvalho DP,

Ferreira ACF. Rutin Scavenges Reactive Oxygen Species, Inactivates 5'-Adenosine

Monophosphate-Activated Protein Kinase, and Increases Sodium-Iodide Symporter

Expression in Thyroid PCCL3 Cells. Thyroid. 2018 Feb;28(2):265-275. doi:

10.1089/thy.2016.0585. Epub 2017 Dec 21. PMID: 29160164.

104: Morra EA, Rodrigues PL, Jesus ICG, Do Val Lima PR, Ávila RA, Zanardo TÉC,

Nogueira BV, Bers DM, Guatimosim S, Stefanon I, Ribeiro Júnior RF. Endurance

training restores spatially distinct cardiac mitochondrial function and

myocardial contractility in ovariectomized rats. Free Radic Biol Med. 2019

Jan;130:174-188. doi: 10.1016/j.freeradbiomed.2018.10.406. Epub 2018 Oct 10.

PMID: 30315935.

105: Kim GT, Lee SH, Kim YM. Torilis japonica extract-generated intracellular

ROS induces apoptosis by reducing the mitochondrial membrane potential via

regulation of the AMPK-p38 MAPK signaling pathway in HCT116 colon cancer. Int J

Oncol. 2016 Sep;49(3):1088-98. doi: 10.3892/ijo.2016.3578. Epub 2016 Jun 16.

PMID: 27314881.

106: Li Y, Li J, Li S, Li Y, Wang X, Liu B, Fu Q, Ma S. Curcumin attenuates

glutamate neurotoxicity in the hippocampus by suppression of ER stress-

associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK.

Toxicol Appl Pharmacol. 2015 Jul 1;286(1):53-63. doi:

10.1016/j.taap.2015.03.010. Epub 2015 Mar 16. PMID: 25791922.

107: Zhao J, Du J, Pan Y, Chen T, Zhao L, Zhu Y, Chen Y, Zheng Y, Liu Y, Sun L,

Hang P, Du Z. Activation of cardiac TrkB receptor by its small molecular agonist

7,8-dihydroxyflavone inhibits doxorubicin-induced cardiotoxicity via enhancing

mitochondrial oxidative phosphorylation. Free Radic Biol Med. 2019

Jan;130:557-567. doi: 10.1016/j.freeradbiomed.2018.11.024. Epub 2018 Nov 22.

PMID: 30472367.

108: Dong HL, Wu HY, Tang Y, Huang YW, Lin RZ, Zhao J, Xu XY. [AMPK regulates

mitochondrial oxidative stress in C2C12 myotubes induced by electrical

stimulations of different intensities]. Nan Fang Yi Ke Da Xue Xue Bao. 2018 Jun

20;38(6):742-747. Chinese. doi: 10.3969/j.issn.1673-4254.2018.06.16. PMID:

29997099; PMCID: PMC6765703.

109: Kogot-Levin A, Saada A, Leibowitz G, Soiferman D, Douiev L, Raz I, Weksler-

Zangen S. Upregulation of Mitochondrial Content in Cytochrome c Oxidase

Deficient Fibroblasts. PLoS One. 2016 Oct 25;11(10):e0165417. doi:

10.1371/journal.pone.0165417. PMID: 27780242; PMCID: PMC5079646.

110: Hu D, Cao S, Zhang G, Xiao Y, Liu S, Shang Y. Florfenicol-induced

Mitochondrial Dysfunction Suppresses Cell Proliferation and Autophagy in

Fibroblasts. Sci Rep. 2017 Oct 19;7(1):13554. doi: 10.1038/s41598-017-13860-9.

PMID: 29051574; PMCID: PMC5648778.

111: Xie Z, Ding SQ, Shen YF. Silibinin activates AMP-activated protein kinase

to protect neuronal cells from oxygen and glucose deprivation-re-oxygenation.

Biochem Biophys Res Commun. 2014 Nov 14;454(2):313-9. doi:

10.1016/j.bbrc.2014.10.080. Epub 2014 Oct 22. PMID: 25450395.

112: Cui J, Li Z, Zhuang S, Qi S, Li L, Zhou J, Zhang W, Zhao Y. Melatonin

alleviates inflammation-induced apoptosis in human umbilical vein endothelial

cells via suppression of Ca<sup>2+</sup>-XO-ROS-Drp1-mitochondrial fission axis

by activation of AMPK/SERCA2a pathway. Cell Stress Chaperones. 2018

Mar;23(2):281-293. doi: 10.1007/s12192-017-0841-6. Epub 2017 Sep 9. PMID:

28889229; PMCID: PMC5823809.

113: Lin CL, Cheng YS, Li HH, Chiu PY, Chang YT, Ho YJ, Lai TJ. Amyloid-β

suppresses AMP-activated protein kinase (AMPK) signaling and contributes to

α-synuclein-induced cytotoxicity. Exp Neurol. 2016 Jan;275 Pt 1:84-98. doi:

10.1016/j.expneurol.2015.10.009. Epub 2015 Oct 26. PMID: 26515689.

114: Julien SG, Kim SY, Brunmeir R, Sinnakannu JR, Ge X, Li H, Ma W, Yaligar J,

Kn BP, Velan SS, Röder PV, Zhang Q, Sim CK, Wu J, Garcia-Miralles M, Pouladi MA,

Xie W, McFarlane C, Han W, Xu F. Narciclasine attenuates diet-induced obesity by

promoting oxidative metabolism in skeletal muscle. PLoS Biol. 2017 Feb

16;15(2):e1002597. doi: 10.1371/journal.pbio.1002597. PMID: 28207742; PMCID:


115: Jiang B, Le L, Pan H, Hu K, Xu L, Xiao P. Dihydromyricetin ameliorates the

oxidative stress response induced by methylglyoxal via the AMPK/GLUT4 signaling

pathway in PC12 cells. Brain Res Bull. 2014 Oct;109:117-26. doi:

10.1016/j.brainresbull.2014.10.010. Epub 2014 Oct 27. PMID: 25451453.

116: Suh KS, Chon S, Choi EM. Limonene protects osteoblasts against

methylglyoxal-derived adduct formation by regulating glyoxalase, oxidative

stress, and mitochondrial function. Chem Biol Interact. 2017 Dec 25;278:15-21.

doi: 10.1016/j.cbi.2017.10.001. Epub 2017 Oct 3. PMID: 28986142.

117: Yu HY, Cai YB, Liu Z. Activation of AMPK improves lipopolysaccharide-

induced dysfunction of the blood-brain barrier in mice. Brain Inj.

2015;29(6):777-84. doi: 10.3109/02699052.2015.1004746. Epub 2015 Mar 20.

Retraction in: Brain Inj. 2018;32(11):1442. PMID: 25794165.

118: Rasheduzzaman M, Yin H, Park SY. Cardiac glycoside sensitized

hepatocellular carcinoma cells to TRAIL via ROS generation, p38MAPK,

mitochondrial transition, and autophagy mediation. Mol Carcinog. 2019

Nov;58(11):2040-2051. doi: 10.1002/mc.23096. Epub 2019 Aug 8. PMID: 31392779.

119: Annesley SJ, Lay ST, De Piazza SW, Sanislav O, Hammersley E, Allan CY,

Francione LM, Bui MQ, Chen ZP, Ngoei KR, Tassone F, Kemp BE, Storey E, Evans A,

Loesch DZ, Fisher PR. Immortalized Parkinson's disease lymphocytes have enhanced

mitochondrial respiratory activity. Dis Model Mech. 2016 Nov 1;9(11):1295-1305.

doi: 10.1242/dmm.025684. Epub 2016 Sep 16. PMID: 27638668; PMCID: PMC5117226.

120: Ward NP, Poff AM, Koutnik AP, D'Agostino DP. Complex I inhibition augments

dichloroacetate cytotoxicity through enhancing oxidative stress in VM-M3

glioblastoma cells. PLoS One. 2017 Jun 23;12(6):e0180061. doi:

10.1371/journal.pone.0180061. PMID: 28644886; PMCID: PMC5482478.

121: Liemburg-Apers DC, Wagenaars JA, Smeitink JA, Willems PH, Koopman WJ. Acute

stimulation of glucose influx upon mitoenergetic dysfunction requires LKB1,

AMPK, Sirt2 and mTOR-RAPTOR. J Cell Sci. 2016 Dec 1;129(23):4411-4423. doi:

10.1242/jcs.194480. Epub 2016 Oct 28. PMID: 27793977.

122: Tan CD, Smolenski RT, Harhun MI, Patel HK, Ahmed SG, Wanisch K, Yáñez-Muñoz

RJ, Baines DL. AMP-activated protein kinase (AMPK)-dependent and -independent

pathways regulate hypoxic inhibition of transepithelial Na+ transport across

human airway epithelial cells. Br J Pharmacol. 2012 Sep;167(2):368-82. doi:

10.1111/j.1476-5381.2012.01993.x. PMID: 22509822; PMCID: PMC3481044.

123: Abdelmegeed MA, Banerjee A, Jang S, Yoo SH, Yun JW, Gonzalez FJ,

Keshavarzian A, Song BJ. CYP2E1 potentiates binge alcohol-induced gut leakiness,

steatohepatitis, and apoptosis. Free Radic Biol Med. 2013 Dec;65:1238-1245. doi:

10.1016/j.freeradbiomed.2013.09.009. Epub 2013 Sep 21. PMID: 24064383; PMCID:


124: Wu SJ, Huang GY, Ng LT. γ-Tocotrienol induced cell cycle arrest and

apoptosis via activating the Bax-mediated mitochondrial and AMPK signaling

pathways in 3T3-L1 adipocytes. Food Chem Toxicol. 2013 Sep;59:501-13. doi:

10.1016/j.fct.2013.06.011. Epub 2013 Jun 29. PMID: 23816832.

125: Jung EH, Jung JY, Ko HL, Kim JK, Park SM, Jung DH, Park CA, Kim YW, Ku SK,

Cho IJ, Kim SC. Tryptanthrin prevents oxidative stress-mediated apoptosis

through AMP-activated protein kinase-dependent p38 mitogen-activated protein

kinase activation. Arch Pharm Res. 2017 Sep;40(9):1071-1086. doi:

10.1007/s12272-017-0947-5. Epub 2017 Aug 21. PMID: 28828587.

126: Li X, Geng J, Liu J. Adiponectin offers protection against L166P mutant

DJ-1-induced neuronal cytotoxicity mediated by APPL1-dependent AMPK activation.

Int J Neurosci. 2014 May;124(5):350-61. doi: 10.3109/00207454.2013.846340. Epub

2013 Oct 29. PMID: 24047115.

127: Xing SS, Yang XY, Zheng T, Li WJ, Wu D, Chi JY, Bian F, Bai XL, Wu GJ,

Zhang YZ, Zhang CT, Zhang YH, Li YS, Jin S. Salidroside improves endothelial

function and alleviates atherosclerosis by activating a mitochondria-related

AMPK/PI3K/Akt/eNOS pathway. Vascul Pharmacol. 2015 Sep;72:141-52. doi:

10.1016/j.vph.2015.07.004. Epub 2015 Jul 15. PMID: 26187353.

128: Barreto-Torres G, Hernandez JS, Jang S, Rodríguez-Muñoz AR, Torres-Ramos

CA, Basnakian AG, Javadov S. The beneficial effects of AMP kinase activation

against oxidative stress are associated with prevention of PPARα-cyclophilin D

interaction in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2015 Apr

1;308(7):H749-58. doi: 10.1152/ajpheart.00414.2014. Epub 2015 Jan 23. PMID:

25617357; PMCID: PMC4385997.

129: Yi D, Hou Y, Xiao H, Wang L, Zhang Y, Chen H, Wu T, Ding B, Hu CA, Wu G.

N-Acetylcysteine improves intestinal function in lipopolysaccharides-challenged

piglets through multiple signaling pathways. Amino Acids. 2017

Dec;49(12):1915-1929. doi: 10.1007/s00726-017-2389-2. Epub 2017 Mar 7. PMID:


130: Zhao H, Zhu H, Lin Z, Lin G, Lv G. Compound 13, an α1-selective small

molecule activator of AMPK, inhibits Helicobacter pylori-induced oxidative

stresses and gastric epithelial cell apoptosis. Biochem Biophys Res Commun. 2015

Aug 7;463(4):510-7. doi: 10.1016/j.bbrc.2015.05.059. Epub 2015 May 27. PMID:


131: Duan P, Hu C, Quan C, Yu T, Zhou W, Yuan M, Shi Y, Yang K. 4-Nonylphenol

induces apoptosis, autophagy and necrosis in Sertoli cells: Involvement of ROS-

mediated AMPK/AKT-mTOR and JNK pathways. Toxicology. 2016 Feb 3;341-343:28-40.

doi: 10.1016/j.tox.2016.01.004. Epub 2016 Jan 19. PMID: 26804764.

132: Zhang J, Qin X, Wang B, Xu G, Qin Z, Wang J, Wu L, Ju X, Bose DD, Qiu F,

Zhou H, Zou Z. Zinc oxide nanoparticles harness autophagy to induce cell death

in lung epithelial cells. Cell Death Dis. 2017 Jul 27;8(7):e2954. doi:

10.1038/cddis.2017.337. PMID: 28749469; PMCID: PMC5550878.

133: Seo HL, Baek SY, Lee EH, Lee JH, Lee SG, Kim KY, Jang MH, Park MH, Kim JH,

Kim KJ, Lee HS, Ahn SC, Lee JR, Park SJ, Kim SC, Kim YW. Liqustri lucidi Fructus

inhibits hepatic injury and functions as an antioxidant by activation of AMP-

activated protein kinase in vivo and in vitro. Chem Biol Interact. 2017 Jan

25;262:57-68. doi: 10.1016/j.cbi.2016.11.031. Epub 2016 Dec 1. PMID: 27916511.

134: Shang SW, Yang JL, Huang F, Liu K, Liu BL. Modified Si-Miao-San ameliorates

pancreatic B cell dysfunction by inhibition of reactive oxygen species-

associated inflammation through AMP-kinase activation. Chin J Nat Med. 2014

May;12(5):351-60. doi: 10.1016/S1875-5364(14)60043-1. PMID: 24856758.

135: Chen TJ, Zhou YF, Ning JJ, Yang T, Ren H, Li Y, Zhang S, Chen MW. NBM-T-

BMX-OS01, an Osthole Derivative, Sensitizes Human Lung Cancer A549 Cells to

Cisplatin through AMPK-Dependent Inhibition of ERK and Akt Pathway. Cell Physiol

Biochem. 2015;36(3):893-906. doi: 10.1159/000430264. Epub 2015 Jun 9. PMID:


136: Tsai HY, Lin CP, Huang PH, Li SY, Chen JS, Lin FY, Chen JW, Lin SJ.

Coenzyme Q10 Attenuates High Glucose-Induced Endothelial Progenitor Cell

Dysfunction through AMP-Activated Protein Kinase Pathways. J Diabetes Res.

2016;2016:6384759. doi: 10.1155/2016/6384759. Epub 2015 Nov 22. PMID: 26682233;

PMCID: PMC4670652.

137: Kamga Pride C, Mo L, Quesnelle K, Dagda RK, Murillo D, Geary L, Corey C,

Portella R, Zharikov S, St Croix C, Maniar S, Chu CT, Khoo NK, Shiva S. Nitrite

activates protein kinase A in normoxia to mediate mitochondrial fusion and

tolerance to ischaemia/reperfusion. Cardiovasc Res. 2014 Jan 1;101(1):57-68.

doi: 10.1093/cvr/cvt224. Epub 2013 Sep 30. PMID: 24081164; PMCID: PMC3868348.

138: Gao XY, Wang SN, Yang XH, Lan WJ, Chen ZW, Chen JK, Xie JH, Han YF, Pi RB,

Yang XB. Gartanin Protects Neurons against Glutamate-Induced Cell Death in HT22

Cells: Independence of Nrf-2 but Involvement of HO-1 and AMPK. Neurochem Res.

2016 Sep;41(9):2267-77. doi: 10.1007/s11064-016-1941-x. Epub 2016 May 9. PMID:


139: Duan WJ, Li YF, Liu FL, Deng J, Wu YP, Yuan WL, Tsoi B, Chen JL, Wang Q,

Cai SH, Kurihara H, He RR. A SIRT3/AMPK/autophagy network orchestrates the

protective effects of trans-resveratrol in stressed peritoneal macrophages and

RAW 264.7 macrophages. Free Radic Biol Med. 2016 Jun;95:230-42. doi:

10.1016/j.freeradbiomed.2016.03.022. Epub 2016 Mar 25. PMID: 27021965.

140: Mahapatra G, Varughese A, Ji Q, Lee I, Liu J, Vaishnav A, Sinkler C,

Kapralov AA, Moraes CT, Sanderson TH, Stemmler TL, Grossman LI, Kagan VE,

Brunzelle JS, Salomon AR, Edwards BF, Hüttemann M. Phosphorylation of Cytochrome

c Threonine 28 Regulates Electron Transport Chain Activity in Kidney:

IMPLICATIONS FOR AMP KINASE. J Biol Chem. 2017 Jan 6;292(1):64-79. doi:

10.1074/jbc.M116.744664. Epub 2016 Oct 7. PMID: 27758862; PMCID: PMC5217700.

141: Meares GP, Hughes KJ, Naatz A, Papa FR, Urano F, Hansen PA, Benveniste EN,

Corbett JA. IRE1-dependent activation of AMPK in response to nitric oxide. Mol

Cell Biol. 2011 Nov;31(21):4286-97. doi: 10.1128/MCB.05668-11. Epub 2011 Sep 6.

PMID: 21896783; PMCID: PMC3209336.

142: Ullah I, Park HY, Kim MO. Anthocyanins protect against kainic acid-induced

excitotoxicity and apoptosis via ROS-activated AMPK pathway in hippocampal

neurons. CNS Neurosci Ther. 2014 Apr;20(4):327-38. doi: 10.1111/cns.12218. Epub

2014 Jan 7. PMID: 24393263; PMCID: PMC6493125.

143: Shafique E, Torina A, Reichert K, Colantuono B, Nur N, Zeeshan K,

Ravichandran V, Liu Y, Feng J, Zeeshan K, Benjamin LE, Irani K, Harrington EO,

Sellke FW, Abid MR. Mitochondrial redox plays a critical role in the paradoxical

effects of NAPDH oxidase-derived ROS on coronary endothelium. Cardiovasc Res.

2017 Feb;113(2):234-246. doi: 10.1093/cvr/cvw249. Epub 2017 Jan 14. PMID:

28088753; PMCID: PMC5340144.

144: Gustafsson AB, Gottlieb RA. Autophagy in ischemic heart disease. Circ Res.

2009 Jan 30;104(2):150-8. doi: 10.1161/CIRCRESAHA.108.187427. PMID: 19179668;

PMCID: PMC2765251.

145: Zakharova IO, Sokolova TV, Bayunova LV, Zorina II, Rychkova MP, Shpakov AO,

Avrova NF. The Protective Effect of Insulin on Rat Cortical Neurons in Oxidative

Stress and Its Dependence on the Modulation of Akt, GSK-3beta, ERK1/2, and AMPK

Activities. Int J Mol Sci. 2019 Jul 29;20(15):3702. doi: 10.3390/ijms20153702.

PMID: 31362343; PMCID: PMC6696072.

146: Behringer M, Montag J, Franz A, McCourt ML, Mester J, Nosaka KK. Exhaustive

exercise--a near death experience for skeletal muscle cells? Med Hypotheses.

2014 Dec;83(6):758-65. doi: 10.1016/j.mehy.2014.10.005. Epub 2014 Oct 13. PMID:


147: Gusarova GA, Dada LA, Kelly AM, Brodie C, Witters LA, Chandel NS, Sznajder

JI. Alpha1-AMP-activated protein kinase regulates hypoxia-induced Na,K-ATPase

endocytosis via direct phosphorylation of protein kinase C zeta. Mol Cell Biol.

2009 Jul;29(13):3455-64. doi: 10.1128/MCB.00054-09. Epub 2009 Apr 20. PMID:

19380482; PMCID: PMC2698765.

148: Bhatt MP, Lim YC, Kim YM, Ha KS. C-peptide activates AMPKα and prevents

ROS-mediated mitochondrial fission and endothelial apoptosis in diabetes.

Diabetes. 2013 Nov;62(11):3851-62. doi: 10.2337/db13-0039. Epub 2013 Jul 24.

PMID: 23884890; PMCID: PMC3806599.

149: Stancic A, Filipovic M, Ivanovic-Burmazovic I, Masovic S, Jankovic A,

Otasevic V, Korac A, Buzadzic B, Korac B. Early energy metabolism-related

molecular events in skeletal muscle of diabetic rats: The effects of l-arginine

and SOD mimic. Chem Biol Interact. 2017 Jun 25;272:188-196. doi:

10.1016/j.cbi.2017.05.003. Epub 2017 May 5. PMID: 28483572.

150: Aoi W, Naito Y, Yoshikawa T. Role of oxidative stress in impaired insulin

signaling associated with exercise-induced muscle damage. Free Radic Biol Med.

2013 Dec;65:1265-1272. doi: 10.1016/j.freeradbiomed.2013.09.014. Epub 2013 Sep

27. PMID: 24075894.

151: Dong GZ, Lee JH, Ki SH, Yang JH, Cho IJ, Kang SH, Zhao RJ, Kim SC, Kim YW.

AMPK activation by isorhamnetin protects hepatocytes against oxidative stress

and mitochondrial dysfunction. Eur J Pharmacol. 2014 Oct 5;740:634-40. doi:

10.1016/j.ejphar.2014.06.017. Epub 2014 Jun 24. PMID: 24972246.

152: Lang F, Münzer P, Gawaz M, Borst O. Regulation of STIM1/Orai1-dependent

Ca2+ signalling in platelets. Thromb Haemost. 2013 Nov;110(5):925-30. doi:

10.1160/TH13-02-0176. Epub 2013 Jul 11. PMID: 23846758.

153: Barbieri E, Guescini M, Calcabrini C, Vallorani L, Diaz AR, Fimognari C,

Canonico B, Luchetti F, Papa S, Battistelli M, Falcieri E, Romanello V, Sandri

M, Stocchi V, Ciacci C, Sestili P. Creatine Prevents the Structural and

Functional Damage to Mitochondria in Myogenic, Oxidatively Stressed C2C12 Cells

and Restores Their Differentiation Capacity. Oxid Med Cell Longev.

2016;2016:5152029. doi: 10.1155/2016/5152029. Epub 2016 Aug 17. PMID: 27610211;

PMCID: PMC5005540.

154: Hall A, Parhamifar L, Lange MK, Meyle KD, Sanderhoff M, Andersen H,

Roursgaard M, Larsen AK, Jensen PB, Christensen C, Bartek J, Moghimi SM.

Polyethylenimine architecture-dependent metabolic imprints and perturbation of

cellular redox homeostasis. Biochim Biophys Acta. 2015 Mar;1847(3):328-342. doi:

10.1016/j.bbabio.2014.12.002. Epub 2014 Dec 5. PMID: 25482261.

155: Peers C, Wyatt CN, Evans AM. Mechanisms for acute oxygen sensing in the

carotid body. Respir Physiol Neurobiol. 2010 Dec 31;174(3):292-8. doi:

10.1016/j.resp.2010.08.010. Epub 2010 Aug 22. PMID: 20736087.

156: Variar G, Pant T, Singh A, Ravichandran A, Swami S, Kalyanaraman B,

Dhanasekaran A. Effect of mitochondrially targeted carboxy proxyl nitroxide on

Akt-mediated survival in Daudi cells: Significance of a dual mode of action.

PLoS One. 2017 Apr 20;12(4):e0174546. doi: 10.1371/journal.pone.0174546. PMID:

28426671; PMCID: PMC5398517.

157: Yang Q, Han L, Li J, Xu H, Liu X, Wang X, Pan C, Lei C, Chen H, Lan X.

Activation of Nrf2 by Phloretin Attenuates Palmitic Acid-Induced Endothelial

Cell Oxidative Stress via AMPK-Dependent Signaling. J Agric Food Chem. 2019 Jan

9;67(1):120-131. doi: 10.1021/acs.jafc.8b05025. Epub 2018 Dec 19. PMID:


158: Lee EH, Baek SY, Park JY, Kim YW. Rifampicin activates AMPK and alleviates

oxidative stress in the liver as mediated with Nrf2 signaling. Chem Biol

Interact. 2020 Jan 5;315:108889. doi: 10.1016/j.cbi.2019.108889. Epub 2019 Nov

1. PMID: 31678598.

159: Liu J, Su H, Qu QM. Carnosic Acid Prevents Beta-Amyloid-Induced Injury in

Human Neuroblastoma SH-SY5Y Cells via the Induction of Autophagy. Neurochem Res.

2016 Sep;41(9):2311-23. doi: 10.1007/s11064-016-1945-6. Epub 2016 May 11. PMID:


160: Li Y, Zhou ZH, Chen MH, Yang J, Leng J, Cao GS, Xin GZ, Liu LF, Kou JP, Liu

BL, Li P, Wen XD. Inhibition of Mitochondrial Fission and NOX2 Expression

Prevent NLRP3 Inflammasome Activation in the Endothelium: The Role of Corosolic

Acid Action in the Amelioration of Endothelial Dysfunction. Antioxid Redox

Signal. 2016 Jun 1;24(16):893-908. doi: 10.1089/ars.2015.6479. Epub 2016 Mar 22.

PMID: 26869350.

161: Banskota S, Regmi SC, Kim JA. NOX1 to NOX2 switch deactivates AMPK and

induces invasive phenotype in colon cancer cells through overexpression of

MMP-7. Mol Cancer. 2015 Jun 27;14:123. doi: 10.1186/s12943-015-0379-0. PMID:

26116564; PMCID: PMC4482031.

162: Mungai PT, Waypa GB, Jairaman A, Prakriya M, Dokic D, Ball MK, Schumacker

PT. Hypoxia triggers AMPK activation through reactive oxygen species-mediated

activation of calcium release-activated calcium channels. Mol Cell Biol. 2011

Sep;31(17):3531-45. doi: 10.1128/MCB.05124-11. Epub 2011 Jun 13. PMID: 21670147;

PMCID: PMC3165558.

163: Lee J, Kim S. Upregulation of heme oxygenase-1 expression by

dehydrodiconiferyl alcohol (DHCA) through the AMPK-Nrf2 dependent pathway.

Toxicol Appl Pharmacol. 2014 Nov 15;281(1):87-100. doi:

10.1016/j.taap.2014.07.011. Epub 2014 Sep 28. PMID: 25261737.

164: Arya A, Gangwar A, Singh SK, Roy M, Das M, Sethy NK, Bhargava K. Cerium

oxide nanoparticles promote neurogenesis and abrogate hypoxia-induced memory

impairment through AMPK-PKC-CBP signaling cascade. Int J Nanomedicine. 2016 Mar

23;11:1159-73. doi: 10.2147/IJN.S102096. PMID: 27069362; PMCID: PMC4818056.

165: Turdi S, Fan X, Li J, Zhao J, Huff AF, Du M, Ren J. AMP-activated protein

kinase deficiency exacerbates aging-induced myocardial contractile dysfunction.

Aging Cell. 2010 Aug;9(4):592-606. doi: 10.1111/j.1474-9726.2010.00586.x. Epub

2010 May 10. PMID: 20477759; PMCID: PMC2910211.

166: Chen J, Lai J, Yang L, Ruan G, Chaugai S, Ning Q, Chen C, Wang DW.

Trimetazidine prevents macrophage-mediated septic myocardial dysfunction via

activation of the histone deacetylase sirtuin 1. Br J Pharmacol. 2016

Feb;173(3):545-61. doi: 10.1111/bph.13386. Epub 2015 Dec 25. PMID: 26566260;

PMCID: PMC4728416.

167: Leverve XM, Guigas B, Detaille D, Batandier C, Koceir EA, Chauvin C,

Fontaine E, Wiernsperger NF. Mitochondrial metabolism and type-2 diabetes: a

specific target of metformin. Diabetes Metab. 2003 Sep;29(4 Pt 2):6S88-94. doi:

10.1016/s1262-3636(03)72792-x. PMID: 14502105.

168: Aldonza MB, Hong JY, Bae SY, Song J, Kim WK, Oh J, Shin Y, Lee SH, Lee SK.

Suppression of MAPK Signaling and Reversal of mTOR-Dependent MDR1-Associated

Multidrug Resistance by 21α-Methylmelianodiol in Lung Cancer Cells. PLoS One.

2015 Jun 22;10(6):e0127841. doi: 10.1371/journal.pone.0127841. Erratum in: PLoS

One. 2015;10(7):e0133922. PMID: 26098947; PMCID: PMC4476707.

169: Tang GJ, Wang HY, Wang JY, Lee CC, Tseng HW, Wu YL, Shyue SK, Lee TS, Kou

YR. Novel role of AMP-activated protein kinase signaling in cigarette smoke

induction of IL-8 in human lung epithelial cells and lung inflammation in mice.

Free Radic Biol Med. 2011 Jun 1;50(11):1492-502. doi:

10.1016/j.freeradbiomed.2011.02.030. Epub 2011 Mar 2. PMID: 21376115.

170: He Y, Zou L, Zhou Y, Hu H, Yao R, Jiang Y, Lau WB, Yuan T, Huang W, Zeng Z,

Cao Y. Adiponectin ameliorates the apoptotic effects of paraquat on alveolar

type Ⅱ cells via improvements in mitochondrial function. Mol Med Rep. 2016

Jul;14(1):746-52. doi: 10.3892/mmr.2016.5328. Epub 2016 May 23. PMID: 27220901;

PMCID: PMC4918546.

171: Trousil S, Kaliszczak M, Schug Z, Nguyen QD, Tomasi G, Favicchio R,

Brickute D, Fortt R, Twyman FJ, Carroll L, Kalusa A, Navaratnam N, Adejumo T,

Carling D, Gottlieb E, Aboagye EO. The novel choline kinase inhibitor ICL-

CCIC-0019 reprograms cellular metabolism and inhibits cancer cell growth.

Oncotarget. 2016 Jun 14;7(24):37103-37120. doi: 10.18632/oncotarget.9466. PMID:

27206796; PMCID: PMC5095062.

172: Choi IY, Ju C, Anthony Jalin AM, Lee DI, Prather PL, Kim WK. Activation of

cannabinoid CB2 receptor-mediated AMPK/CREB pathway reduces cerebral ischemic

injury. Am J Pathol. 2013 Mar;182(3):928-39. doi: 10.1016/j.ajpath.2012.11.024.

Epub 2013 Feb 13. PMID: 23414569.

173: Ou HC, Hsieh YL, Yang NC, Tsai KL, Chen KL, Tsai CS, Chen IJ, Wu BT, Lee

SD. Ginkgo biloba extract attenuates oxLDL-induced endothelial dysfunction via

an AMPK-dependent mechanism. J Appl Physiol (1985). 2013 Jan 15;114(2):274-85.

doi: 10.1152/japplphysiol.00367.2012. Epub 2012 Nov 29. PMID: 23195633.

174: Salt IP, Connell JM, Gould GW. 5-aminoimidazole-4-carboxamide

ribonucleoside (AICAR) inhibits insulin-stimulated glucose transport in 3T3-L1

adipocytes. Diabetes. 2000 Oct;49(10):1649-56. doi: 10.2337/diabetes.49.10.1649.

PMID: 11016448.

175: Chien SY, Huang CY, Tsai CH, Wang SW, Lin YM, Tang CH. Interleukin-1β

induces fibroblast growth factor 2 expression and subsequently promotes

endothelial progenitor cell angiogenesis in chondrocytes. Clin Sci (Lond). 2016

May;130(9):667-81. doi: 10.1042/CS20150622. Epub 2016 Jan 25. PMID: 26811540;

PMCID: PMC4797417.

176: Chen Y, Qing W, Sun M, Lv L, Guo D, Jiang Y. Melatonin protects hepatocytes

against bile acid-induced mitochondrial oxidative stress via the AMPK-SIRT3-SOD2

pathway. Free Radic Res. 2015 Oct;49(10):1275-84. doi:

10.3109/10715762.2015.1067806. PMID: 26118716.

177: Erusalimsky JD, Moncada S. Nitric oxide and mitochondrial signaling: from

physiology to pathophysiology. Arterioscler Thromb Vasc Biol. 2007

Dec;27(12):2524-31. doi: 10.1161/ATVBAHA.107.151167. Epub 2007 Sep 20. PMID:


178: Kim GT, Lee SH, Kim JI, Kim YM. Quercetin regulates the sestrin 2-AMPK-p38

MAPK signaling pathway and induces apoptosis by increasing the generation of

intracellular ROS in a p53-independent manner. Int J Mol Med. 2014

Apr;33(4):863-9. doi: 10.3892/ijmm.2014.1658. Epub 2014 Feb 13. PMID: 24535669;

PMCID: PMC3976123.

179: Le Guen M, Chaté V, Hininger-Favier I, Laillet B, Morio B, Pieroni G,

Schlattner U, Pison C, Dubouchaud H. A 9-wk docosahexaenoic acid-enriched

supplementation improves endurance exercise capacity and skeletal muscle

mitochondrial function in adult rats. Am J Physiol Endocrinol Metab. 2016 Feb

1;310(3):E213-24. doi: 10.1152/ajpendo.00468.2014. Epub 2015 Dec 8. PMID:


180: Bonora M, De Marchi E, Patergnani S, Suski JM, Celsi F, Bononi A, Giorgi C,

Marchi S, Rimessi A, Duszyński J, Pozzan T, Wieckowski MR, Pinton P. Tumor

necrosis factor-α impairs oligodendroglial differentiation through a

mitochondria-dependent process. Cell Death Differ. 2014 Aug;21(8):1198-208. doi:

10.1038/cdd.2014.35. Epub 2014 Mar 21. PMID: 24658399; PMCID: PMC4085526.

181: Zhao Q, Sun Y, Ji Y, Xu L, Liu K, Liu B, Huang F. Total polyphenol of

Anemarrhena asphodeloides ameliorates advanced glycation end products-induced

endothelial dysfunction by regulation of AMP-Kinase. J Diabetes. 2014

Jul;6(4):304-15. doi: 10.1111/1753-0407.12111. Epub 2014 Jan 9. PMID: 24245915.

182: Youn JY, Wang T, Cai H. An ezrin/calpain/PI3K/AMPK/eNOSs1179 signaling

cascade mediating VEGF-dependent endothelial nitric oxide production. Circ Res.

2009 Jan 2;104(1):50-9. doi: 10.1161/CIRCRESAHA.108.178467. Epub 2008 Nov 26.

PMID: 19038867; PMCID: PMC2720268.

183: Marton O, Koltai E, Takeda M, Koch LG, Britton SL, Davies KJ, Boldogh I,

Radak Z. Mitochondrial biogenesis-associated factors underlie the magnitude of

response to aerobic endurance training in rats. Pflugers Arch. 2015

Apr;467(4):779-88. doi: 10.1007/s00424-014-1554-7. Epub 2014 Jun 19. PMID:

24943897; PMCID: PMC4272336.

184: Walker J, Jijon HB, Churchill T, Kulka M, Madsen KL. Activation of AMP-

activated protein kinase reduces cAMP-mediated epithelial chloride secretion. Am

J Physiol Gastrointest Liver Physiol. 2003 Nov;285(5):G850-60. doi:

10.1152/ajpgi.00077.2003. Epub 2003 Jul 17. PMID: 12869384.

185: Hou XB, Li TH, Ren ZP, Liu Y. Combination of 2-deoxy d-glucose and

metformin for synergistic inhibition of non-small cell lung cancer: A reactive

oxygen species and P-p38 mediated mechanism. Biomed Pharmacother. 2016

Dec;84:1575-1584. doi: 10.1016/j.biopha.2016.10.037. Epub 2016 Nov 5. PMID:


186: Ou HC, Lee WJ, Wu CM, Chen JF, Sheu WH. Aspirin prevents resistin-induced

endothelial dysfunction by modulating AMPK, ROS, and Akt/eNOS signaling. J Vasc

Surg. 2012 Apr;55(4):1104-15. doi: 10.1016/j.jvs.2011.10.011. Epub 2012 Jan 14.

PMID: 22244860.

187: Soltoff SP. Rottlerin: an inappropriate and ineffective inhibitor of

PKCdelta. Trends Pharmacol Sci. 2007 Sep;28(9):453-8. doi:

10.1016/ Epub 2007 Aug 10. PMID: 17692392.

188: Shafique E, Choy WC, Liu Y, Feng J, Cordeiro B, Lyra A, Arafah M, Yassin-

Kassab A, Zanetti AV, Clements RT, Bianchi C, Benjamin LE, Sellke FW, Abid MR.

Oxidative stress improves coronary endothelial function through activation of

the pro-survival kinase AMPK. Aging (Albany NY). 2013 Jul;5(7):515-30. doi:

10.18632/aging.100569. PMID: 24018842; PMCID: PMC3765580.

189: Herranz-López M, Barrajón-Catalán E, Segura-Carretero A, Menéndez JA, Joven

J, Micol V. Lemon verbena (Lippia citriodora) polyphenols alleviate obesity-

related disturbances in hypertrophic adipocytes through AMPK-dependent

mechanisms. Phytomedicine. 2015 Jun 1;22(6):605-14. doi:

10.1016/j.phymed.2015.03.015. Epub 2015 Apr 10. PMID: 26055125.

190: Xing S, Yang X, Li W, Bian F, Wu D, Chi J, Xu G, Zhang Y, Jin S.

Salidroside stimulates mitochondrial biogenesis and protects against H₂O₂-

induced endothelial dysfunction. Oxid Med Cell Longev. 2014;2014:904834. doi:

10.1155/2014/904834. Epub 2014 Apr 24. PMID: 24868319; PMCID: PMC4020198.

191: Song J, Li J, Hou F, Wang X, Liu B. Mangiferin inhibits endoplasmic

reticulum stress-associated thioredoxin-interacting protein/NLRP3 inflammasome

activation with regulation of AMPK in endothelial cells. Metabolism. 2015

Mar;64(3):428-37. doi: 10.1016/j.metabol.2014.11.008. Epub 2014 Nov 28. PMID:


192: Kornelius E, Lin CL, Chang HH, Li HH, Huang WN, Yang YS, Lu YL, Peng CH,

Huang CN. DPP-4 Inhibitor Linagliptin Attenuates Aβ-induced Cytotoxicity through

Activation of AMPK in Neuronal Cells. Version 2. CNS Neurosci Ther. 2015

Jul;21(7):549-57. doi: 10.1111/cns.12404. Epub 2015 May 26. PMID: 26010513;

PMCID: PMC5033019.

193: Yans A, Shahamati SZ, Maghsoudi AH, Maghsoudi N. Digitoflavone provokes

mitochondrial biogenesis in PC12 cells: A protective approach to oxidative

stress. Pharm Biol. 2015;53(12):1727-34. doi: 10.3109/13880209.2015.1005749.

Epub 2015 Apr 9. PMID: 25856707.

194: Son MJ, Minakawa M, Miura Y, Yagasaki K. Aspalathin improves hyperglycemia

and glucose intolerance in obese diabetic ob/ob mice. Eur J Nutr. 2013

Sep;52(6):1607-19. doi: 10.1007/s00394-012-0466-6. Epub 2012 Dec 13. PMID:


195: Hall DD, Wu Y, Domann FE, Spitz DR, Anderson ME. Mitochondrial calcium

uniporter activity is dispensable for MDA-MB-231 breast carcinoma cell survival.

PLoS One. 2014 May 6;9(5):e96866. doi: 10.1371/journal.pone.0096866. PMID:

24802861; PMCID: PMC4011874.

196: Moir H, Hughes MG, Potter S, Sims C, Butcher LR, Davies NA, Verheggen K,

Jones KP, Thomas AW, Webb R. Exercise-induced immunosuppression: roles of

reactive oxygen species and 5'-AMP-activated protein kinase dephosphorylation

within immune cells. J Appl Physiol (1985). 2010 May;108(5):1284-92. doi:

10.1152/japplphysiol.00737.2009. Epub 2010 Feb 18. PMID: 20167678.

197: Li YH, Yang LY, Chen W, Li YK, Yuan HB. Fibroblast growth factor 10

protects neuron against oxygen-glucose deprivation injury through inducing heme

oxygenase-1. Biochem Biophys Res Commun. 2015 Jan 2;456(1):225-31. doi:

10.1016/j.bbrc.2014.11.063. Epub 2014 Nov 22. PMID: 25446127.

198: Wu HM, Lee CG, Hwang SJ, Kim SG. Mitigation of carbon tetrachloride-induced

hepatic injury by methylene blue, a repurposed drug, is mediated by dual

inhibition of GSK3β downstream of PKA. Br J Pharmacol. 2014

Jun;171(11):2790-802. doi: 10.1111/bph.12637. PMID: 24641162; PMCID: PMC4243855.

199: Fu X, Wan S, Lyu YL, Liu LF, Qi H. Etoposide induces ATM-dependent

mitochondrial biogenesis through AMPK activation. PLoS One. 2008 Apr

23;3(4):e2009. doi: 10.1371/journal.pone.0002009. PMID: 18431490; PMCID:


200: Lu S, Xu D. Cold stress accentuates pressure overload-induced cardiac

hypertrophy and contractile dysfunction: role of TRPV1/AMPK-mediated autophagy.

Biochem Biophys Res Commun. 2013 Dec 6;442(1-2):8-15. doi:

10.1016/j.bbrc.2013.10.128. Epub 2013 Nov 5. PMID: 24211590.

201: Hwang JT, Ha J, Park IJ, Lee SK, Baik HW, Kim YM, Park OJ. Apoptotic effect

of EGCG in HT-29 colon cancer cells via AMPK signal pathway. Cancer Lett. 2007

Mar 8;247(1):115-21. doi: 10.1016/j.canlet.2006.03.030. Epub 2006 Jun 21. PMID:


202: Piwkowska A, Rogacka D, Angielski S, Jankowski M. Hydrogen peroxide induces

activation of insulin signaling pathway via AMP-dependent kinase in podocytes.

Biochem Biophys Res Commun. 2012 Nov 9;428(1):167-72. doi:

10.1016/j.bbrc.2012.10.033. Epub 2012 Oct 12. PMID: 23068094.

203: Li M, Tang YQ, Du RH, Shi FH, Hussein HK, Dai DZ, Dai Y. CPUY11018, an

azimilide derivative, ameliorates isoproterenol-induced cardiac insufficiency

through relieving dysfunctional mitochondria and endoplasmic reticulum. J Pharm

Pharmacol. 2015 Aug;67(8):1029-41. doi: 10.1111/jphp.12401. Epub 2015 Apr 1.

PMID: 25828246.

204: Tang Y, Li J, Li F, Hu CA, Liao P, Tan K, Tan B, Xiong X, Liu G, Li T, Yin

Y. Autophagy protects intestinal epithelial cells against deoxynivalenol

toxicity by alleviating oxidative stress via IKK signaling pathway. Free Radic

Biol Med. 2015 Dec;89:944-51. doi: 10.1016/j.freeradbiomed.2015.09.012. Epub

2015 Oct 9. PMID: 26456059.

205: Zhao Y, Li Q, Zhao W, Li J, Sun Y, Liu K, Liu B, Zhang N. Astragaloside IV

and cycloastragenol are equally effective in inhibition of endoplasmic reticulum

stress-associated TXNIP/NLRP3 inflammasome activation in the endothelium. J

Ethnopharmacol. 2015 Jul 1;169:210-8. doi: 10.1016/j.jep.2015.04.030. Epub 2015

Apr 25. PMID: 25922268.

206: Chantong B, Kratschmar DV, Lister A, Odermatt A. Dibutyltin promotes

oxidative stress and increases inflammatory mediators in BV-2 microglia cells.

Toxicol Lett. 2014 Oct 15;230(2):177-87. doi: 10.1016/j.toxlet.2014.03.001. Epub

2014 Mar 13. PMID: 24631921.

207: Kim WH, Lee JW, Suh YH, Lee HJ, Lee SH, Oh YK, Gao B, Jung MH. AICAR

potentiates ROS production induced by chronic high glucose: roles of AMPK in

pancreatic beta-cell apoptosis. Cell Signal. 2007 Apr;19(4):791-805. doi:

10.1016/j.cellsig.2006.10.004. Epub 2006 Nov 28. PMID: 17127032.

208: Tang H, Pan CS, Mao XW, Liu YY, Yan L, Zhou CM, Fan JY, Zhang SY, Han JY.

Role of NADPH oxidase in total salvianolic acid injection attenuating ischemia-

reperfusion impaired cerebral microcirculation and neurons: implication of

AMPK/Akt/PKC. Microcirculation. 2014 Oct;21(7):615-27. doi: 10.1111/micc.12140.

PMID: 24702968.

209: Lee JW, Kim WH, Yeo J, Jung MH. ER stress is implicated in mitochondrial

dysfunction-induced apoptosis of pancreatic beta cells. Mol Cells. 2010

Dec;30(6):545-9. doi: 10.1007/s10059-010-0161-5. Epub 2010 Dec 3. PMID:


210: Zhang X, Zhu P, Zhang X, Ma Y, Li W, Chen JM, Guo HM, Bucala R, Zhuang J,

Li J. Natural antioxidant-isoliquiritigenin ameliorates contractile dysfunction

of hypoxic cardiomyocytes via AMPK signaling pathway. Mediators Inflamm.

2013;2013:390890. doi: 10.1155/2013/390890. Epub 2013 Sep 16. PMID: 24163504;

PMCID: PMC3791876.

211: Kumar P, Phil D. Translating blood-borne stimuli: chemotransduction in the

carotid body. Sheng Li Xue Bao. 2007 Apr 25;59(2):128-32. PMID: 17437033.

212: Zhang Y, Mi SL, Hu N, Doser TA, Sun A, Ge J, Ren J. Mitochondrial aldehyde

dehydrogenase 2 accentuates aging-induced cardiac remodeling and contractile

dysfunction: role of AMPK, Sirt1, and mitochondrial function. Free Radic Biol

Med. 2014 Jun;71:208-20. doi: 10.1016/j.freeradbiomed.2014.03.018. Epub 2014 Mar

24. PMID: 24675227; PMCID: PMC4068748.

213: Jang W, Kim HJ, Li H, Jo KD, Lee MK, Song SH, Yang HO.

1,25-Dyhydroxyvitamin D₃ attenuates rotenone-induced neurotoxicity in SH-SY5Y

cells through induction of autophagy. Biochem Biophys Res Commun. 2014 Aug

15;451(1):142-7. doi: 10.1016/j.bbrc.2014.07.081. Epub 2014 Jul 29. PMID:


214: Perng DW, Chang TM, Wang JY, Lee CC, Lu SH, Shyue SK, Lee TS, Kou YR.

Inflammatory role of AMP-activated protein kinase signaling in an experimental

model of toxic smoke inhalation injury. Crit Care Med. 2013 Jan;41(1):120-32.

doi: 10.1097/CCM.0b013e318265f653. PMID: 23222262.

215: Gusarova GA, Trejo HE, Dada LA, Briva A, Welch LC, Hamanaka RB, Mutlu GM,

Chandel NS, Prakriya M, Sznajder JI. Hypoxia leads to Na,K-ATPase downregulation

via Ca(2+) release-activated Ca(2+) channels and AMPK activation. Mol Cell Biol.

2011 Sep;31(17):3546-56. doi: 10.1128/MCB.05114-11. Epub 2011 Jul 5. PMID:

21730292; PMCID: PMC3165547.

216: Akimoto M, Iizuka M, Kanematsu R, Yoshida M, Takenaga K. Anticancer Effect

of Ginger Extract against Pancreatic Cancer Cells Mainly through Reactive Oxygen

Species-Mediated Autotic Cell Death. PLoS One. 2015 May 11;10(5):e0126605. doi:

10.1371/journal.pone.0126605. PMID: 25961833; PMCID: PMC4427290.

217: Zhang H, Liu YY, Jiang Q, Li KR, Zhao YX, Cao C, Yao J. Salvianolic acid A

protects RPE cells against oxidative stress through activation of Nrf2/HO-1

signaling. Free Radic Biol Med. 2014 Apr;69:219-28. doi:

10.1016/j.freeradbiomed.2014.01.025. Epub 2014 Jan 28. PMID: 24486344.

218: Shin SM, Cho IJ, Kim SG. Resveratrol protects mitochondria against

oxidative stress through AMP-activated protein kinase-mediated glycogen synthase

kinase-3beta inhibition downstream of poly(ADP-ribose)polymerase-LKB1 pathway.

Mol Pharmacol. 2009 Oct;76(4):884-95. doi: 10.1124/mol.109.058479. Epub 2009 Jul

20. Erratum in: Mol Pharmacol. 2019 Feb;95(2):152-154. PMID: 19620254.

219: Ha JH, Noh HS, Shin IW, Hahm JR, Kim DR. Mitigation of H2O2-induced

autophagic cell death by propofol in H9c2 cardiomyocytes. Cell Biol Toxicol.

2012 Feb;28(1):19-29. doi: 10.1007/s10565-011-9202-x. Epub 2011 Sep 12. PMID:


220: Kim MJ, Nagy LE, Park PH. Globular adiponectin inhibits ethanol-induced

reactive oxygen species production through modulation of NADPH oxidase in

macrophages: involvement of liver kinase B1/AMP-activated protein kinase

pathway. Mol Pharmacol. 2014 Sep;86(3):284-96. doi: 10.1124/mol.114.093039. Epub

2014 May 21. PMID: 24850909; PMCID: PMC6067636.

221: Liu J, Li J, Zhang JF, Xin XY. Combination of fenretinide and selenite

inhibits proliferation and induces apoptosis in ovarian cancer cells. Int J Mol

Sci. 2013 Nov 4;14(11):21790-804. doi: 10.3390/ijms141121790. PMID: 24192821;

PMCID: PMC3856035.

222: Zheng A, Li H, Xu J, Cao K, Li H, Pu W, Yang Z, Peng Y, Long J, Liu J, Feng

Z. Hydroxytyrosol improves mitochondrial function and reduces oxidative stress

in the brain of db/db mice: role of AMP-activated protein kinase activation. Br

J Nutr. 2015 Jun 14;113(11):1667-76. doi: 10.1017/S0007114515000884. Epub 2015

Apr 17. PMID: 25885653.

223: Zhou X, Chen M, Zeng X, Yang J, Deng H, Yi L, Mi MT. Resveratrol regulates

mitochondrial reactive oxygen species homeostasis through Sirt3 signaling

pathway in human vascular endothelial cells. Cell Death Dis. 2014 Dec

18;5(12):e1576. doi: 10.1038/cddis.2014.530. PMID: 25522270; PMCID: PMC4454164.

224: Rodenak-Kladniew B, Castro A, Stärkel P, Galle M, Crespo R. 1,8-Cineole

promotes G0/G1 cell cycle arrest and oxidative stress-induced senescence in

HepG2 cells and sensitizes cells to anti-senescence drugs. Life Sci. 2020 Feb

15;243:117271. doi: 10.1016/j.lfs.2020.117271. Epub 2020 Jan 8. PMID: 31926243.

225: Wu XL, Liou CJ, Li ZY, Lai XY, Fang LW, Huang WC. Sesamol suppresses the

inflammatory response by inhibiting NF-κB/MAPK activation and upregulating AMP

kinase signaling in RAW 264.7 macrophages. Inflamm Res. 2015 Aug;64(8):577-88.

doi: 10.1007/s00011-015-0836-7. Epub 2015 Jun 10. PMID: 26059394.

226: Sook SH, Lee HJ, Kim JH, Sohn EJ, Jung JH, Kim B, Kim JH, Jeong SJ, Kim SH.

Reactive oxygen species-mediated activation of AMP-activated protein kinase and

c-Jun N-terminal kinase plays a critical role in beta-sitosterol-induced

apoptosis in multiple myeloma U266 cells. Phytother Res. 2014 Mar;28(3):387-94.

doi: 10.1002/ptr.4999. Epub 2013 May 3. PMID: 23640957.

227: Koo JH, Lee WH, Lee CG, Kim SG. Fyn inhibition by cycloalkane-fused

1,2-dithiole-3-thiones enhances antioxidant capacity and protects mitochondria

from oxidative injury. Mol Pharmacol. 2012 Jul;82(1):27-36. doi:

10.1124/mol.111.077149. Epub 2012 Apr 2. PMID: 22474169.

228: Li J, Li J, Yue Y, Hu Y, Cheng W, Liu R, Pan X, Zhang P. Genistein

suppresses tumor necrosis factor α-induced inflammation via modulating reactive

oxygen species/Akt/nuclear factor κB and adenosine monophosphate-activated

protein kinase signal pathways in human synoviocyte MH7A cells. Drug Des Devel

Ther. 2014 Mar 17;8:315-23. doi: 10.2147/DDDT.S52354. PMID: 24669186; PMCID:


229: Wang X, Wang Q, Sun Z. Normal IgG downregulates the intracellular

superoxide level and attenuates migration and permeability in human aortic

endothelial cells isolated from a hypertensive patient. Hypertension. 2012

Sep;60(3):818-26. doi: 10.1161/HYPERTENSIONAHA.112.199281. Epub 2012 Jul 9.

PMID: 22777940; PMCID: PMC3421057.

230: Kang C, Kim E. Synergistic effect of curcumin and insulin on muscle cell

glucose metabolism. Food Chem Toxicol. 2010 Aug-Sep;48(8-9):2366-73. doi:

10.1016/j.fct.2010.05.073. Epub 2010 Jun 1. PMID: 20561944.

231: Lee HR, Kim J, Park J, Ahn S, Jeong E, Park H. FERM domain promotes

resveratrol-induced apoptosis in endothelial cells via inhibition of NO

production. Biochem Biophys Res Commun. 2013 Nov 29;441(4):891-6. doi:

10.1016/j.bbrc.2013.10.154. Epub 2013 Nov 6. PMID: 24211585.

232: Shao FY, Du ZY, Ma DL, Chen WB, Fu WY, Ruan BB, Rui W, Zhang JX, Wang S,

Wong NS, Xiao H, Li MM, Liu X, Liu QY, Zhou XD, Yan HZ, Wang YF, Chen CY, Liu Z,

Chen HY. B5, a thioredoxin reductase inhibitor, induces apoptosis in human

cervical cancer cells by suppressing the thioredoxin system, disrupting

mitochondrion-dependent pathways and triggering autophagy. Oncotarget. 2015 Oct

13;6(31):30939-56. doi: 10.18632/oncotarget.5132. PMID: 26439985; PMCID:


233: Horie T, Ono K, Nagao K, Nishi H, Kinoshita M, Kawamura T, Wada H, Shimatsu

A, Kita T, Hasegawa K. Oxidative stress induces GLUT4 translocation by

activation of PI3-K/Akt and dual AMPK kinase in cardiac myocytes. J Cell

Physiol. 2008 Jun;215(3):733-42. doi: 10.1002/jcp.21353. PMID: 18163380.

234: Ceolotto G, Gallo A, Papparella I, Franco L, Murphy E, Iori E, Pagnin E,

Fadini GP, Albiero M, Semplicini A, Avogaro A. Rosiglitazone reduces glucose-

induced oxidative stress mediated by NAD(P)H oxidase via AMPK-dependent

mechanism. Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2627-33. doi:

10.1161/ATVBAHA.107.155762. Epub 2007 Oct 4. PMID: 17916771.

235: Qin S, Rodrigues GA. Differential roles of AMPKα1 and AMPKα2 in regulating

4-HNE-induced RPE cell death and permeability. Exp Eye Res. 2010

Dec;91(6):818-24. doi: 10.1016/j.exer.2010.10.007. Epub 2010 Oct 26. PMID:


236: Xi H, Barredo JC, Merchan JR, Lampidis TJ. Endoplasmic reticulum stress

induced by 2-deoxyglucose but not glucose starvation activates AMPK through

CaMKKβ leading to autophagy. Biochem Pharmacol. 2013 May 15;85(10):1463-77. doi:

10.1016/j.bcp.2013.02.037. Epub 2013 Mar 13. PMID: 23500541.

237: Teodoro JS, Duarte FV, Gomes AP, Varela AT, Peixoto FM, Rolo AP, Palmeira

CM. Berberine reverts hepatic mitochondrial dysfunction in high-fat fed rats: a

possible role for SirT3 activation. Mitochondrion. 2013 Nov;13(6):637-46. doi:

10.1016/j.mito.2013.09.002. Epub 2013 Sep 14. PMID: 24041461.

238: Kwon YN, Shin SM, Cho IJ, Kim SG. Oxidized metabolites of oltipraz exert

cytoprotective effects against arachidonic acid through AMP-activated protein

kinase-dependent cellular antioxidant effect and mitochondrial protection. Drug

Metab Dispos. 2009 Jun;37(6):1187-97. doi: 10.1124/dmd.108.025908. Epub 2009 Mar

19. PMID: 19299524.

239: Kim YW, Lee SM, Shin SM, Hwang SJ, Brooks JS, Kang HE, Lee MG, Kim SC, Kim

SG. Efficacy of sauchinone as a novel AMPK-activating lignan for preventing

iron-induced oxidative stress and liver injury. Free Radic Biol Med. 2009 Oct

1;47(7):1082-92. doi: 10.1016/j.freeradbiomed.2009.07.018. Epub 2009 Jul 17.

PMID: 19616619.

240: Tsai KL, Chen LH, Chiou SH, Chiou GY, Chen YC, Chou HY, Chen LK, Chen HY,

Chiu TH, Tsai CS, Ou HC, Kao CL. Coenzyme Q10 suppresses oxLDL-induced

endothelial oxidative injuries by the modulation of LOX-1-mediated ROS

generation via the AMPK/PKC/NADPH oxidase signaling pathway. Mol Nutr Food Res.

2011 Sep;55 Suppl 2:S227-40. doi: 10.1002/mnfr.201100147. Epub 2011 Aug 3. PMID:


241: Wang XM, Song SS, Xiao H, Gao P, Li XJ, Si LY. Fibroblast growth factor 21

protects against high glucose induced cellular damage and dysfunction of

endothelial nitric-oxide synthase in endothelial cells. Cell Physiol Biochem.

2014;34(3):658-71. doi: 10.1159/000363031. Epub 2014 Aug 13. PMID: 25170746.

242: Shen B, He PJ, Shao CL. Norcantharidin induced DU145 cell apoptosis through

ROS-mediated mitochondrial dysfunction and energy depletion. PLoS One. 2013 Dec

19;8(12):e84610. doi: 10.1371/journal.pone.0084610. PMID: 24367681; PMCID:


243: Lee YH, Wang E, Kumar N, Glickman RD. Ursolic acid differentially modulates

apoptosis in skin melanoma and retinal pigment epithelial cells exposed to UV-

VIS broadband radiation. Apoptosis. 2014 May;19(5):816-28. doi:

10.1007/s10495-013-0962-z. PMID: 24375173.

244: Whiteside C, Wang H, Xia L, Munk S, Goldberg HJ, Fantus IG. Rosiglitazone

prevents high glucose-induced vascular endothelial growth factor and collagen IV

expression in cultured mesangial cells. Exp Diabetes Res. 2009;2009:910783. doi:

10.1155/2009/910783. Epub 2009 Jul 7. PMID: 19609456; PMCID: PMC2709725.

245: Moiseeva O, Bourdeau V, Roux A, Deschênes-Simard X, Ferbeyre G.

Mitochondrial dysfunction contributes to oncogene-induced senescence. Mol Cell

Biol. 2009 Aug;29(16):4495-507. doi: 10.1128/MCB.01868-08. Epub 2009 Jun 15.

PMID: 19528227; PMCID: PMC2725737.

246: Han C, Zhao Q, Lu B. The role of nitric oxide signaling in food intake;

insights from the inner mitochondrial membrane peptidase 2 mutant mice. Redox

Biol. 2013 Oct 24;1(1):498-507. doi: 10.1016/j.redox.2013.10.003. PMID:

24251118; PMCID: PMC3830068.

247: Filomeni G, Piccirillo S, Graziani I, Cardaci S, Da Costa Ferreira AM,

Rotilio G, Ciriolo MR. The isatin-Schiff base copper(II) complex Cu(isaepy)2

acts as delocalized lipophilic cation, yields widespread mitochondrial oxidative

damage and induces AMP-activated protein kinase-dependent apoptosis.

Carcinogenesis. 2009 Jul;30(7):1115-24. doi: 10.1093/carcin/bgp105. Epub 2009

Apr 30. PMID: 19406932; PMCID: PMC2722147.

248: Budinger GR, Urich D, DeBiase PJ, Chiarella SE, Burgess ZO, Baker CM,

Soberanes S, Mutlu GM, Jones JC. Stretch-induced activation of AMP kinase in the

lung requires dystroglycan. Am J Respir Cell Mol Biol. 2008 Dec;39(6):666-72.

doi: 10.1165/rcmb.2007-0432OC. Epub 2008 Jun 12. PMID: 18556591; PMCID:


249: Pignochino Y, Dell'Aglio C, Basiricò M, Capozzi F, Soster M, Marchiò S,

Bruno S, Gammaitoni L, Sangiolo D, Torchiaro E, D'Ambrosio L, Fagioli F, Ferrari

S, Alberghini M, Picci P, Aglietta M, Grignani G. The Combination of Sorafenib

and Everolimus Abrogates mTORC1 and mTORC2 upregulation in osteosarcoma

preclinical models. Clin Cancer Res. 2013 Apr 15;19(8):2117-31. doi:

10.1158/1078-0432.CCR-12-2293. Epub 2013 Feb 22. PMID: 23434734.

250: Wang X, Liu R, Zhang W, Zhang X, Liao N, Wang Z, Li W, Qin X, Hai C.

Oleanolic acid improves hepatic insulin resistance via antioxidant,

hypolipidemic and anti-inflammatory effects. Mol Cell Endocrinol. 2013 Aug

25;376(1-2):70-80. doi: 10.1016/j.mce.2013.06.014. Epub 2013 Jun 18. PMID:


251: Blättler SM, Rencurel F, Kaufmann MR, Meyer UA. In the regulation of

cytochrome P450 genes, phenobarbital targets LKB1 for necessary activation of

AMP-activated protein kinase. Proc Natl Acad Sci U S A. 2007 Jan

16;104(3):1045-50. doi: 10.1073/pnas.0610216104. Epub 2007 Jan 9. PMID:

17213310; PMCID: PMC1783361.

252: Alba G, El Bekay R, Alvarez-Maqueda M, Chacón P, Vega A, Monteseirín J,

Santa María C, Pintado E, Bedoya FJ, Bartrons R, Sobrino F. Stimulators of AMP-

activated protein kinase inhibit the respiratory burst in human neutrophils.

FEBS Lett. 2004 Aug 27;573(1-3):219-25. doi: 10.1016/j.febslet.2004.07.077.

PMID: 15328001.

253: Choi YW, Park TJ, Kim HS, Lim IK. Signals regulating necrosis of

cardiomyoblast by BTG2(/TIS21/PC3) via activation of GSK3β and opening of

mitochondrial permeability transition pore in response to H2O2. Biochem Biophys

Res Commun. 2013 May 10;434(3):559-65. doi: 10.1016/j.bbrc.2013.03.114. Epub

2013 Apr 11. PMID: 23583382.

254: Xiao J, Sun B, Li M, Wu Y, Sun XB. A novel adipocytokine visfatin protects

against H(2)O(2) -induced myocardial apoptosis: a missing link between obesity

and cardiovascular disease. J Cell Physiol. 2013 Mar;228(3):495-501. doi:

10.1002/jcp.24257. PMID: 23065734.

255: Tovilovic G, Zogovic N, Harhaji-Trajkovic L, Misirkic-Marjanovic M,

Janjetovic K, Vucicevic L, Kostic-Rajacic S, Schrattenholz A, Isakovic A, Soskic

V, Trajkovic V. Arylpiperazine dopamineric ligands protect neuroblastoma cells

from nitric oxide (NO)-induced mitochondrial damage and apoptosis. ChemMedChem.

2012 Mar 5;7(3):495-508. doi: 10.1002/cmdc.201100537. Epub 2012 Feb 1. PMID:


256: Andrews ZB, Liu ZW, Walllingford N, Erion DM, Borok E, Friedman JM, Tschöp

MH, Shanabrough M, Cline G, Shulman GI, Coppola A, Gao XB, Horvath TL, Diano S.

UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals.

Nature. 2008 Aug 14;454(7206):846-51. doi: 10.1038/nature07181. Epub 2008 Jul

30. PMID: 18668043; PMCID: PMC4101536.

257: Sarkar S, Korolchuk VI, Renna M, Imarisio S, Fleming A, Williams A, Garcia-

Arencibia M, Rose C, Luo S, Underwood BR, Kroemer G, O'Kane CJ, Rubinsztein DC.

Complex inhibitory effects of nitric oxide on autophagy. Mol Cell. 2011 Jul

8;43(1):19-32. doi: 10.1016/j.molcel.2011.04.029. PMID: 21726807; PMCID:


258: Canabal DD, Potian JG, Duran RG, McArdle JJ, Routh VH. Hyperglycemia

impairs glucose and insulin regulation of nitric oxide production in glucose-

inhibited neurons in the ventromedial hypothalamus. Am J Physiol Regul Integr

Comp Physiol. 2007 Aug;293(2):R592-600. doi: 10.1152/ajpregu.00207.2007. Epub

2007 May 30. PMID: 17537841.

259: Wang J, Alexanian A, Ying R, Kizhakekuttu TJ, Dharmashankar K, Vasquez-

Vivar J, Gutterman DD, Widlansky ME. Acute exposure to low glucose rapidly

induces endothelial dysfunction and mitochondrial oxidative stress: role for AMP

kinase. Arterioscler Thromb Vasc Biol. 2012 Mar;32(3):712-20. doi:

10.1161/ATVBAHA.111.227389. Epub 2011 Dec 29. PMID: 22207730; PMCID: PMC3319449.

260: Chedid P, Hurtado-Nedelec M, Marion-Gaber B, Bournier O, Hayem G, Gougerot-

Pocidalo MA, Frystyk J, Flyvbjerg A, El Benna J, Marie JC. Adiponectin and its

globular fragment differentially modulate the oxidative burst of primary human

phagocytes. Am J Pathol. 2012 Feb;180(2):682-92. doi:

10.1016/j.ajpath.2011.10.013. Epub 2011 Nov 23. PMID: 22119038.

261: Canabal DD, Song Z, Potian JG, Beuve A, McArdle JJ, Routh VH. Glucose,

insulin, and leptin signaling pathways modulate nitric oxide synthesis in

glucose-inhibited neurons in the ventromedial hypothalamus. Am J Physiol Regul

Integr Comp Physiol. 2007 Apr;292(4):R1418-28. doi: 10.1152/ajpregu.00216.2006.

Epub 2006 Dec 14. PMID: 17170237.

262: Sartoretto JL, Kalwa H, Shiroto T, Sartoretto SM, Pluth MD, Lippard SJ,

Michel T. Role of Ca2+ in the control of H2O2-modulated phosphorylation pathways

leading to eNOS activation in cardiac myocytes. PLoS One. 2012;7(9):e44627. doi:

10.1371/journal.pone.0044627. Epub 2012 Sep 6. PMID: 22970272; PMCID:


263: Davis B, Rahman A, Arner A. AMP-activated kinase relaxes agonist induced

contractions in the mouse aorta via effects on PKC signaling and inhibits NO-

induced relaxation. Eur J Pharmacol. 2012 Nov 15;695(1-3):88-95. doi:

10.1016/j.ejphar.2012.07.025. Epub 2012 Aug 19. PMID: 22921370.

264: Zhang X, Yeung ED, Wang J, Panzhinskiy EE, Tong C, Li W, Li J.

Isoliquiritigenin, a natural anti-oxidant, selectively inhibits the

proliferation of prostate cancer cells. Clin Exp Pharmacol Physiol. 2010

Aug;37(8):841-7. doi: 10.1111/j.1440-1681.2010.05395.x. Epub 2010 Apr 26. PMID:


265: Shin SM, Kim SG. Inhibition of arachidonic acid and iron-induced

mitochondrial dysfunction and apoptosis by oltipraz and novel

1,2-dithiole-3-thione congeners. Mol Pharmacol. 2009 Jan;75(1):242-53. doi:

10.1124/mol.108.051128. Epub 2008 Oct 22. PMID: 18945820.

266: Schulz E, Dopheide J, Schuhmacher S, Thomas SR, Chen K, Daiber A, Wenzel P,

Münzel T, Keaney JF Jr. Suppression of the JNK pathway by induction of a

metabolic stress response prevents vascular injury and dysfunction. Circulation.

2008 Sep 23;118(13):1347-57. doi: 10.1161/CIRCULATIONAHA.108.784298. PMID:

18809807; PMCID: PMC2756193.

267: Cai XJ, Li CJ, Chen L, Rong YY, Zhang Y, Zhang M. A hypothesis: adiponectin

mediates anti-atherosclerosis via adventitia-AMPK-iNOS pathway. Med Hypotheses.

2008;70(5):1044-7. doi: 10.1016/j.mehy.2007.08.012. Epub 2007 Oct 29. PMID:


268: Sun YW, Huang WJ, Hsiao CJ, Chen YC, Lu PH, Guh JH. Methoxychalcone induces

cell-cycle arrest and apoptosis in human hormone-resistant prostate cancer cells

through PI 3-kinase-independent inhibition of mTOR pathways. Prostate. 2010 Sep

1;70(12):1295-306. doi: 10.1002/pros.21165. PMID: 20623631.

269: Lei B, Matsuo K, Labinskyy V, Sharma N, Chandler MP, Ahn A, Hintze TH,

Stanley WC, Recchia FA. Exogenous nitric oxide reduces glucose transporters

translocation and lactate production in ischemic myocardium in vivo. Proc Natl

Acad Sci U S A. 2005 May 10;102(19):6966-71. doi: 10.1073/pnas.0500768102. Epub

2005 May 3. PMID: 15870202; PMCID: PMC1100777.

270: Lee BW, Kwon SJ, Chae HY, Kang JG, Kim CS, Lee SJ, Yoo HJ, Kim JH, Park KS,

Ihm SH. Dose-related cytoprotective effect of alpha-lipoic acid on hydrogen

peroxide-induced oxidative stress to pancreatic beta cells. Free Radic Res. 2009

Jan;43(1):68-77. doi: 10.1080/10715760802590400. PMID: 19358002.

271: Wensveen FM, Alves NL, Derks IA, Reedquist KA, Eldering E. Apoptosis

induced by overall metabolic stress converges on the Bcl-2 family proteins Noxa

and Mcl-1. Apoptosis. 2011 Jul;16(7):708-21. doi: 10.1007/s10495-011-0599-8.

PMID: 21516346; PMCID: PMC3098366.

272: Gundewar S, Calvert JW, Jha S, Toedt-Pingel I, Ji SY, Nunez D, Ramachandran

A, Anaya-Cisneros M, Tian R, Lefer DJ. Activation of AMP-activated protein

kinase by metformin improves left ventricular function and survival in heart

failure. Circ Res. 2009 Feb 13;104(3):403-11. doi:

10.1161/CIRCRESAHA.108.190918. Epub 2008 Dec 18. PMID: 19096023; PMCID:


273: Martini C, Pallottini V, De Marinis E, Marino M, Cavallini G, Donati A,

Straniero S, Trentalance A. Omega-3 as well as caloric restriction prevent the

age-related modifications of cholesterol metabolism. Mech Ageing Dev. 2008

Dec;129(12):722-7. doi: 10.1016/j.mad.2008.09.010. Epub 2008 Sep 26. PMID:


274: Galal O, Podlogar J, Verspohl EJ. Impact of ADMA (asymmetric

dimethylarginine) on physiology with respect to diabetes mellitus and

respiratory system BEAS-2B cells (human bronchial epithelial cells). J Pharm

Pharmacol. 2013 Feb;65(2):253-63. doi: 10.1111/j.2042-7158.2012.01590.x. Epub

2012 Sep 26. PMID: 23278693.

275: Cidad P, Almeida A, Bolaños JP. Inhibition of mitochondrial respiration by

nitric oxide rapidly stimulates cytoprotective GLUT3-mediated glucose uptake

through 5'-AMP-activated protein kinase. Biochem J. 2004 Dec 15;384(Pt

3):629-36. doi: 10.1042/BJ20040886. PMID: 15320870; PMCID: PMC1134149.

276: Alvero AB, Montagna MK, Holmberg JC, Craveiro V, Brown D, Mor G. Targeting

the mitochondria activates two independent cell death pathways in ovarian cancer

stem cells. Mol Cancer Ther. 2011 Aug;10(8):1385-93. doi:

10.1158/1535-7163.MCT-11-0023. Epub 2011 Jun 15. PMID: 21677151; PMCID:


277: Ling LU, Tan KB, Lin H, Chiu GN. The role of reactive oxygen species and

autophagy in safingol-induced cell death. Cell Death Dis. 2011 Mar 10;2(3):e129.

doi: 10.1038/cddis.2011.12. PMID: 21390063; PMCID: PMC3101809.

278: Han M, Im DS. Effects of mitochondrial inhibitors on cell viability in U937

monocytes under glucose deprivation. Arch Pharm Res. 2008 Jun;31(6):749-57. doi:

10.1007/s12272-001-1222-5. Epub 2008 Jun 19. PMID: 18563357.

279: Turdi S, Ge W, Hu N, Bradley KM, Wang X, Ren J. Interaction between

maternal and postnatal high fat diet leads to a greater risk of myocardial

dysfunction in offspring via enhanced lipotoxicity, IRS-1 serine phosphorylation

and mitochondrial defects. J Mol Cell Cardiol. 2013 Feb;55:117-29. doi:

10.1016/j.yjmcc.2012.12.007. Epub 2012 Dec 22. PMID: 23266593.

280: Ding S, Riddoch-Contreras J, Abramov AY, Qi Z, Duchen MR. Mild stress of

caffeine increased mtDNA content in skeletal muscle cells: the interplay between

Ca2+ transients and nitric oxide. J Muscle Res Cell Motil. 2012

Oct;33(5):327-37. doi: 10.1007/s10974-012-9318-5. Epub 2012 Aug 25. Erratum in:

J Muscle Res Cell Motil. 2012 Oct;33(5):339. Contrevas, Joanna R [corrected to

Riddoch-Contreras, Joanna]. PMID: 22926241.

281: Isakovic A, Harhaji L, Stevanovic D, Markovic Z, Sumarac-Dumanovic M,

Starcevic V, Micic D, Trajkovic V. Dual antiglioma action of metformin: cell

cycle arrest and mitochondria-dependent apoptosis. Cell Mol Life Sci. 2007

May;64(10):1290-302. doi: 10.1007/s00018-007-7080-4. PMID: 17447005.

282: Golubitzky A, Dan P, Weissman S, Link G, Wikstrom JD, Saada A. Screening

for active small molecules in mitochondrial complex I deficient patient's

fibroblasts, reveals AICAR as the most beneficial compound. PLoS One.

2011;6(10):e26883. doi: 10.1371/journal.pone.0026883. Epub 2011 Oct 26. PMID:

22046392; PMCID: PMC3202581.

283: Ceylan-Isik AF, Zhao P, Zhang B, Xiao X, Su G, Ren J. Cardiac

overexpression of metallothionein rescues cardiac contractile dysfunction and

endoplasmic reticulum stress but not autophagy in sepsis. J Mol Cell Cardiol.

2010 Feb;48(2):367-78. doi: 10.1016/j.yjmcc.2009.11.003. Epub 2009 Nov 13. PMID:

19914257; PMCID: PMC2813369.

284: Arab A, Kuemmerer K, Wang J, Bode C, Hehrlein C. Oxygenated

perfluorochemicals improve cell survival during reoxygenation by pacifying

mitochondrial activity. J Pharmacol Exp Ther. 2008 May;325(2):417-24. doi:

10.1124/jpet.107.133710. Epub 2008 Feb 27. PMID: 18305017.

285: Khaliulin I, Clarke SJ, Lin H, Parker J, Suleiman MS, Halestrap AP.

Temperature preconditioning of isolated rat hearts--a potent cardioprotective

mechanism involving a reduction in oxidative stress and inhibition of the

mitochondrial permeability transition pore. J Physiol. 2007 Jun 15;581(Pt

3):1147-61. doi: 10.1113/jphysiol.2007.130369. Epub 2007 Mar 29. PMID: 17395631;

PMCID: PMC1976396.

286: Schuhmacher S, Foretz M, Knorr M, Jansen T, Hortmann M, Wenzel P, Oelze M,

Kleschyov AL, Daiber A, Keaney JF Jr, Wegener G, Lackner K, Münzel T, Viollet B,

Schulz E. α1AMP-activated protein kinase preserves endothelial function during

chronic angiotensin II treatment by limiting Nox2 upregulation. Arterioscler

Thromb Vasc Biol. 2011 Mar;31(3):560-6. doi: 10.1161/ATVBAHA.110.219543. Epub

2011 Jan 4. PMID: 21205985; PMCID: PMC3066307.

287: Yuan F, Liu YH, Tian JW, Peng YM, Liu FY. [Renoprotective effect of

adiponectin through an antioxidant mechanism in streptozotocin- induced diabetic

rats]. Nan Fang Yi Ke Da Xue Xue Bao. 2010 Mar;30(3):426-30. Chinese. PMID:


288: Khaliulin IG, Maslov LN, Podoksenov IuK, Lishmanov IuB. [Signalling

mechanisms of cardioprotective effect of hypothermic preconditioning]. Ross

Fiziol Zh Im I M Sechenova. 2011 Jun;97(6):624-32. Russian. PMID: 21874875.

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